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Discovery of Nelutroctiv (CK-136), a Selective Cardiac Troponin Activator for the Treatment of Cardiovascular Diseases Associated with Reduced Cardiac Contractility.
Romero A, Ashcraft L, Chandra A, DiMassa V, Cremin P, Collibee SE, Chuang C, Hartman J, Hwee DT, St Jean D, Malinowski J, DeBenedetto M, Moebius D, Payette J, Vargas R, Yeoman J, Motani A, Reagan J, Malik FI, Morgan BP. Romero A, et al. Among authors: cremin p. J Med Chem. 2024 May 23;67(10):7825-7835. doi: 10.1021/acs.jmedchem.3c02413. Epub 2024 May 10. J Med Chem. 2024. PMID: 38729623 Free PMC article.
Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy.
Chuang C, Collibee S, Ashcraft L, Wang W, Vander Wal M, Wang X, Hwee DT, Wu Y, Wang J, Chin ER, Cremin P, Zamora J, Hartman J, Schaletzky J, Wehri E, Robertson LA, Malik FI, Morgan BP. Chuang C, et al. Among authors: cremin p. J Med Chem. 2021 Oct 14;64(19):14142-14152. doi: 10.1021/acs.jmedchem.1c01290. Epub 2021 Oct 4. J Med Chem. 2021. PMID: 34606259 Free article.
Bacterial biofilm inhibitors from Diospyros dendo.
Hu JF, Garo E, Goering MG, Pasmore M, Yoo HD, Esser T, Sestrich J, Cremin PA, Hough GW, Perrone P, Lee YS, Le NT, O'Neil-Johnson M, Costerton JW, Eldridge GR. Hu JF, et al. Among authors: cremin pa. J Nat Prod. 2006 Jan;69(1):118-20. doi: 10.1021/np049600s. J Nat Prod. 2006. PMID: 16441080
16 results