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Randomized, open-label, phase 2a study to evaluate the contribution of artefenomel to the clinical and parasiticidal activity of artefenomel plus ferroquine in African patients with uncomplicated Plasmodium falciparum malaria.
Gansane A, Lingani M, Yeka A, Nahum A, Bouyou-Akotet M, Mombo-Ngoma G, Kaguthi G, Barceló C, Laurijssens B, Cantalloube C, Macintyre F, Djeriou E, Jessel A, Bejuit R, Demarest H, Marrast AC, Debe S, Tinto H, Kibuuka A, Nahum D, Mawili-Mboumba DP, Zoleko-Manego R, Mugenya I, Olewe F, Duparc S, Ogutu B. Gansane A, et al. Among authors: laurijssens b. Malar J. 2023 Jan 3;22(1):2. doi: 10.1186/s12936-022-04420-2. Malar J. 2023. PMID: 36597076 Free PMC article. Clinical Trial.
A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria.
Adoke Y, Zoleko-Manego R, Ouoba S, Tiono AB, Kaguthi G, Bonzela JE, Duong TT, Nahum A, Bouyou-Akotet M, Ogutu B, Ouedraogo A, Macintyre F, Jessel A, Laurijssens B, Cherkaoui-Rbati MH, Cantalloube C, Marrast AC, Bejuit R, White D, Wells TNC, Wartha F, Leroy D, Kibuuka A, Mombo-Ngoma G, Ouattara D, Mugenya I, Phuc BQ, Bohissou F, Mawili-Mboumba DP, Olewe F, Soulama I, Tinto H; FALCI Study Group. Adoke Y, et al. Among authors: laurijssens b. Malar J. 2021 May 19;20(1):222. doi: 10.1186/s12936-021-03749-4. Malar J. 2021. PMID: 34011358 Free PMC article. Clinical Trial.
African isolates show a high proportion of multiple copies of the Plasmodium falciparum plasmepsin-2 gene, a piperaquine resistance marker.
Leroy D, Macintyre F, Adoke Y, Ouoba S, Barry A, Mombo-Ngoma G, Ndong Ngomo JM, Varo R, Dossou Y, Tshefu AK, Duong TT, Phuc BQ, Laurijssens B, Klopper R, Khim N, Legrand E, Ménard D. Leroy D, et al. Among authors: laurijssens b. Malar J. 2019 Apr 10;18(1):126. doi: 10.1186/s12936-019-2756-4. Malar J. 2019. PMID: 30967148 Free PMC article. Clinical Trial.
A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria.
Macintyre F, Adoke Y, Tiono AB, Duong TT, Mombo-Ngoma G, Bouyou-Akotet M, Tinto H, Bassat Q, Issifou S, Adamy M, Demarest H, Duparc S, Leroy D, Laurijssens BE, Biguenet S, Kibuuka A, Tshefu AK, Smith M, Foster C, Leipoldt I, Kremsner PG, Phuc BQ, Ouedraogo A, Ramharter M; OZ-Piperaquine Study Group. Macintyre F, et al. Among authors: laurijssens be. BMC Med. 2017 Oct 9;15(1):181. doi: 10.1186/s12916-017-0940-3. BMC Med. 2017. PMID: 28988541 Free PMC article. Clinical Trial.
Animal models of Alzheimer's disease and drug development.
Laurijssens B, Aujard F, Rahman A. Laurijssens B, et al. Drug Discov Today Technol. 2013 Sep;10(3):e319-27. doi: 10.1016/j.ddtec.2012.04.001. Drug Discov Today Technol. 2013. PMID: 24050129 Review.
A randomized, double-blind, placebo-controlled trial to assess the efficacy and safety of gabapentin enacarbil in subjects with neuropathic pain associated with postherpetic neuralgia (PXN110748).
Zhang L, Rainka M, Freeman R, Harden RN, Bell CF, Chen C, Graff O, Harding K, Hunter S, Kavanagh S, Laurijssens B, Schwartzbach C, Warren S, McClung C. Zhang L, et al. Among authors: laurijssens b. J Pain. 2013 Jun;14(6):590-603. doi: 10.1016/j.jpain.2013.01.768. Epub 2013 Apr 18. J Pain. 2013. PMID: 23602345 Free article. Clinical Trial.
Prolonged pharmacodynamic effects of S-0139, an intravenously administered endothelin A (ET) antagonist, in the human forearm blood flow model.
Lunnon MW, Wallace SM, Palmer JE, Francis-Lang A, Laurijssens BE, Mistry P, Albala B, Nagafuji T, Wilkinson IB, Maltby K. Lunnon MW, et al. Among authors: laurijssens be. Br J Clin Pharmacol. 2010 Mar;69(3):252-61. doi: 10.1111/j.1365-2125.2009.03590.x. Br J Clin Pharmacol. 2010. PMID: 20233196 Free PMC article.
15 results