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Collaborative Virtual Screening Identifies a 2-Aryl-4-aminoquinazoline Series with Efficacy in an In Vivo Model of Trypanosoma cruzi Infection.
Tawaraishi T, Ochida A, Akao Y, Itono S, Kamaura M, Akther T, Shimada M, Canan S, Chowdhury S, Cao Y, Condroski K, Engkvist O, Francisco A, Ghosh S, Kaki R, Kelly JM, Kimura C, Kogej T, Nagaoka K, Naito A, Pairaudeau G, Radu C, Roberts I, Shum D, Watanabe NA, Xie H, Yonezawa S, Yoshida O, Yoshida R, Mowbray C, Perry B. Tawaraishi T, et al. Among authors: naito a. J Med Chem. 2023 Jan 26;66(2):1221-1238. doi: 10.1021/acs.jmedchem.2c00775. Epub 2023 Jan 6. J Med Chem. 2023. PMID: 36607408 Free PMC article.
Collaborative virtual screening to elaborate an imidazo[1,2-a]pyridine hit series for visceral leishmaniasis.
Akao Y, Canan S, Cao Y, Condroski K, Engkvist O, Itono S, Kaki R, Kimura C, Kogej T, Nagaoka K, Naito A, Nakai H, Pairaudeau G, Radu C, Roberts I, Shimada M, Shum D, Watanabe NA, Xie H, Yonezawa S, Yoshida O, Yoshida R, Mowbray C, Perry B. Akao Y, et al. Among authors: naito a. RSC Med Chem. 2021 Jan 21;12(3):384-393. doi: 10.1039/d0md00353k. RSC Med Chem. 2021. PMID: 34041487 Free PMC article.
Baloxavir marboxil, a novel cap-dependent endonuclease inhibitor potently suppresses influenza virus replication and represents therapeutic effects in both immunocompetent and immunocompromised mouse models.
Fukao K, Ando Y, Noshi T, Kitano M, Noda T, Kawai M, Yoshida R, Sato A, Shishido T, Naito A. Fukao K, et al. Among authors: naito a. PLoS One. 2019 May 20;14(5):e0217307. doi: 10.1371/journal.pone.0217307. eCollection 2019. PLoS One. 2019. PMID: 31107922 Free PMC article.
The antiviral effects of baloxavir marboxil against influenza A virus infection in ferrets.
Kitano M, Matsuzaki T, Oka R, Baba K, Noda T, Yoshida Y, Sato K, Kiyota K, Mizutare T, Yoshida R, Sato A, Kamimori H, Shishido T, Naito A. Kitano M, et al. Among authors: naito a. Influenza Other Respir Viruses. 2020 Nov;14(6):710-719. doi: 10.1111/irv.12760. Epub 2020 Jun 13. Influenza Other Respir Viruses. 2020. PMID: 32533654 Free PMC article.
Pharmacokinetic and pharmacodynamic analysis of baloxavir marboxil, a novel cap-dependent endonuclease inhibitor, in a murine model of influenza virus infection.
Ando Y, Noshi T, Sato K, Ishibashi T, Yoshida Y, Hasegawa T, Onishi M, Kitano M, Oka R, Kawai M, Yoshida R, Sato A, Shishido T, Naito A. Ando Y, et al. Among authors: naito a. J Antimicrob Chemother. 2021 Jan 1;76(1):189-198. doi: 10.1093/jac/dkaa393. J Antimicrob Chemother. 2021. PMID: 33035324 Free PMC article.
In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit.
Noshi T, Kitano M, Taniguchi K, Yamamoto A, Omoto S, Baba K, Hashimoto T, Ishida K, Kushima Y, Hattori K, Kawai M, Yoshida R, Kobayashi M, Yoshinaga T, Sato A, Okamatsu M, Sakoda Y, Kida H, Shishido T, Naito A. Noshi T, et al. Among authors: naito a. Antiviral Res. 2018 Dec;160:109-117. doi: 10.1016/j.antiviral.2018.10.008. Epub 2018 Oct 11. Antiviral Res. 2018. PMID: 30316915 Free article.
Identification of cap-dependent endonuclease inhibitors with broad-spectrum activity against bunyaviruses.
Toba S, Sato A, Kawai M, Taoda Y, Unoh Y, Kusakabe S, Nobori H, Uehara S, Uemura K, Taniguchi K, Kobayashi M, Noshi T, Yoshida R, Naito A, Shishido T, Maruyama J, Paessler S, Carr MJ, Hall WW, Yoshimatsu K, Arikawa J, Matsuno K, Sakoda Y, Sasaki M, Orba Y, Sawa H, Kida H. Toba S, et al. Among authors: naito a. Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2206104119. doi: 10.1073/pnas.2206104119. Epub 2022 Aug 29. Proc Natl Acad Sci U S A. 2022. PMID: 36037386 Free PMC article.
797 results