Houk KN - Search Results

1

Molecular Dynamics Simulations Guide Chimeragenesis and Engineered Control of Chemoselectivity in Diketopiperazine Dimerases.

Shende VV, Harris NR, Sanders JN, Newmister SA, Khatri Y, Movassaghi M, Houk KN, Sherman DH. Shende VV, et al. Among authors: houk kn. Angew Chem Int Ed Engl. 2023 May 8;62(20):e202210254. doi: 10.1002/anie.202210254. Epub 2023 Feb 17. Angew Chem Int Ed Engl. 2023. PMID: 36610039 Free PMC article.

2

Enzymatic hydroxylation of an unactivated methylene C-H bond guided by molecular dynamics simulations.

Narayan AR, Jiménez-Osés G, Liu P, Negretti S, Zhao W, Gilbert MM, Ramabhadran RO, Yang YF, Furan LR, Li Z, Podust LM, Montgomery J, Houk KN, Sherman DH. Narayan AR, et al. Among authors: houk kn. Nat Chem. 2015 Aug;7(8):653-60. doi: 10.1038/nchem.2285. Epub 2015 Jun 29. Nat Chem. 2015. PMID: 26201742 Free PMC article.

3

Function and Structure of MalA/MalA', Iterative Halogenases for Late-Stage C-H Functionalization of Indole Alkaloids.

Fraley AE, Garcia-Borràs M, Tripathi A, Khare D, Mercado-Marin EV, Tran H, Dan Q, Webb GP, Watts KR, Crews P, Sarpong R, Williams RM, Smith JL, Houk KN, Sherman DH. Fraley AE, et al. Among authors: houk kn. J Am Chem Soc. 2017 Aug 30;139(34):12060-12068. doi: 10.1021/jacs.7b06773. Epub 2017 Aug 21. J Am Chem Soc. 2017. PMID: 28777910 Free PMC article.

4

A Single Active Site Mutation in the Pikromycin Thioesterase Generates a More Effective Macrocyclization Catalyst.

Koch AA, Hansen DA, Shende VV, Furan LR, Houk KN, Jiménez-Osés G, Sherman DH. Koch AA, et al. Among authors: houk kn. J Am Chem Soc. 2017 Sep 27;139(38):13456-13465. doi: 10.1021/jacs.7b06436. Epub 2017 Sep 19. J Am Chem Soc. 2017. PMID: 28836768 Free PMC article.

5

Synthesis of Diverse 11- and 12-Membered Macrolactones from a Common Linear Substrate Using a Single Biocatalyst.

Gilbert MM, DeMars MD 2nd, Yang S, Grandner JM, Wang S, Wang H, Narayan ARH, Sherman DH, Houk KN, Montgomery J. Gilbert MM, et al. Among authors: houk kn. ACS Cent Sci. 2017 Dec 27;3(12):1304-1310. doi: 10.1021/acscentsci.7b00450. Epub 2017 Nov 15. ACS Cent Sci. 2017. PMID: 29296671 Free PMC article.

6

Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis.

Newmister SA, Li S, Garcia-Borràs M, Sanders JN, Yang S, Lowell AN, Yu F, Smith JL, Williams RM, Houk KN, Sherman DH. Newmister SA, et al. Among authors: houk kn. Nat Chem Biol. 2018 Apr;14(4):345-351. doi: 10.1038/s41589-018-0003-x. Epub 2018 Mar 12. Nat Chem Biol. 2018. PMID: 29531360 Free PMC article.

7

Enzymatic control of dioxygen binding and functionalization of the flavin cofactor.

Saleem-Batcha R, Stull F, Sanders JN, Moore BS, Palfey BA, Houk KN, Teufel R. Saleem-Batcha R, et al. Among authors: houk kn. Proc Natl Acad Sci U S A. 2018 May 8;115(19):4909-4914. doi: 10.1073/pnas.1801189115. Epub 2018 Apr 23. Proc Natl Acad Sci U S A. 2018. PMID: 29686059 Free PMC article.

8

Design of catalysts for site-selective and enantioselective functionalization of non-activated primary C-H bonds.

Liao K, Yang YF, Li Y, Sanders JN, Houk KN, Musaev DG, Davies HML. Liao K, et al. Among authors: houk kn. Nat Chem. 2018 Oct;10(10):1048-1055. doi: 10.1038/s41557-018-0087-7. Epub 2018 Aug 6. Nat Chem. 2018. PMID: 30082883 Free PMC article.

9

Mechanism of Permanganate-Promoted Dihydroxylation of Complex Diketopiperazines: Critical Roles of Counter-cation and Ion-Pairing.

Haines BE, Nelson BM, Grandner JM, Kim J, Houk KN, Movassaghi M, Musaev DG. Haines BE, et al. Among authors: houk kn. J Am Chem Soc. 2018 Oct 17;140(41):13375-13386. doi: 10.1021/jacs.8b08371. Epub 2018 Oct 8. J Am Chem Soc. 2018. PMID: 30295476 Free PMC article.

10

Controlling, Understanding, and Redirecting the Thermal Rearrangement of 3,3-Dicyano-1,5-enynes.

Scott SK, Sanders JN, White KE, Yu RA, Houk KN, Grenning AJ. Scott SK, et al. Among authors: houk kn. J Am Chem Soc. 2018 Nov 28;140(47):16134-16139. doi: 10.1021/jacs.8b08553. Epub 2018 Nov 12. J Am Chem Soc. 2018. PMID: 30379070 Free PMC article.

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