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Historical evaluation of the in vivo adventitious virus test and its potential for replacement with next generation sequencing (NGS).
Barone PW, Keumurian FJ, Neufeld C, Koenigsberg A, Kiss R, Leung J, Wiebe M, Ait-Belkacem R, Azimpour Tabrizi C, Barbirato C, Beurdeley P, Brussel A, Cassart JP, Cote C, Deneyer N, Dheenadhayalan V, Diaz L, Geiselhoeringer A, Gilleece MM, Goldmann J, Hickman D, Holden A, Keiner B, Kopp M, Kreil TR, Lambert C, Logvinoff C, Michaels B, Modrof J, Mullan B, Mullberg J, Murphy M, O'Donnell S, Peña J, Ruffing M, Ruppach H, Salehi N, Shaid S, Silva L, Snyder R, Spedito-Jovial M, Vandeputte O, Westrek B, Yang B, Yang P, Springs SL. Barone PW, et al. Biologicals. 2023 Feb;81:101661. doi: 10.1016/j.biologicals.2022.11.003. Epub 2023 Jan 6. Biologicals. 2023. PMID: 36621353 Free article.
Mechanistic modeling explains the production dynamics of recombinant adeno-associated virus with the baculovirus expression vector system.
Destro F, Joseph J, Srinivasan P, Kanter JM, Neufeld C, Wolfrum JM, Barone PW, Springs SL, Sinskey AJ, Cecchini S, Kotin RM, Braatz RD. Destro F, et al. Among authors: barone pw. Mol Ther Methods Clin Dev. 2023 Jun 2;30:122-146. doi: 10.1016/j.omtm.2023.05.019. eCollection 2023 Sep 14. Mol Ther Methods Clin Dev. 2023. PMID: 37746245 Free PMC article.
Multidose transient transfection of human embryonic kidney 293 cells modulates recombinant adeno-associated virus2/5 Rep protein expression and influences the enrichment fraction of filled capsids.
Srinivasan P, Canova CT, Sha S, Nguyen TNT, Joseph J, Sangerman J, Maloney AJ, Katsikis G, Ou RW, Hong MS, Ng J, Yuan A, Antov D, Song S, Chen W, Neufeld C, Wolfrum JM, Barone PW, Sinskey AJ, Springs SL, Braatz RD. Srinivasan P, et al. Among authors: barone pw. Biotechnol Bioeng. 2024 Dec;121(12):3694-3714. doi: 10.1002/bit.28828. Epub 2024 Aug 23. Biotechnol Bioeng. 2024. PMID: 39176568
MIT CAACB Risk Assessment Case Study: Assessing Virus Cross-Contamination Risk between Two Simultaneous Processes in an Open Biomanufacturing Facility.
Koenigsberg AL, Fowler V, Domike R, Brussel A, Barone PW, Keumurian FJ, Leung J, Wiebe ME, Brewer MT, Chan S, Dumey N, Fournillier A, Goodnight M, Kindermann J, Leavy R, Lee B, Minning S, Murphy M, Myers E, Nahabedian A, Nanda K, Parriott S, Raju GK, Scallan C, Schoch S, Shiminsky J, Shum B, Teitz S, Westrek B, Springs SL. Koenigsberg AL, et al. Among authors: barone pw. PDA J Pharm Sci Technol. 2023 Mar-Apr;77(2):115-132. doi: 10.5731/pdajpst.2021.012691. Epub 2022 Oct 14. PDA J Pharm Sci Technol. 2023. PMID: 36241212
43 results