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Page 1
Discovery of Potent and Exquisitely Selective Inhibitors of Kinase CK1 with Tunable Isoform Selectivity.
Němec V, Khirsariya P, Janovská P, Moyano PM, Maier L, Procházková P, Kebková P, Gybel' T, Berger BT, Chaikuad A, Reinecke M, Kuster B, Knapp S, Bryja V, Paruch K. Němec V, et al. Among authors: janovska p. Angew Chem Int Ed Engl. 2023 Mar 6;62(11):e202217532. doi: 10.1002/anie.202217532. Epub 2023 Feb 2. Angew Chem Int Ed Engl. 2023. PMID: 36625768
The planar cell polarity pathway drives pathogenesis of chronic lymphocytic leukemia by the regulation of B-lymphocyte migration.
Kaucká M, Plevová K, Pavlová S, Janovská P, Mishra A, Verner J, Procházková J, Krejcí P, Kotasková J, Ovesná P, Tichy B, Brychtová Y, Doubek M, Kozubík A, Mayer J, Pospísilová S, Bryja V. Kaucká M, et al. Among authors: janovska p. Cancer Res. 2013 Mar 1;73(5):1491-501. doi: 10.1158/0008-5472.CAN-12-1752. Epub 2013 Jan 21. Cancer Res. 2013. PMID: 23338609
ROR1-based immunomagnetic protocol allows efficient separation of CLL and healthy B cells.
Kotašková J, Pavlová Š, Greif I, Stehlíková O, Plevová K, Janovská P, Brychtová Y, Doubek M, Pospíšilová Š, Bryja V. Kotašková J, et al. Among authors: janovska p. Br J Haematol. 2016 Oct;175(2):339-342. doi: 10.1111/bjh.13848. Epub 2015 Nov 16. Br J Haematol. 2016. PMID: 26567475 Free article. No abstract available.
Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cells.
Zemanova J, Hylse O, Collakova J, Vesely P, Oltova A, Borsky M, Zaprazna K, Kasparkova M, Janovska P, Verner J, Kohoutek J, Dzimkova M, Bryja V, Jaskova Z, Brychtova Y, Paruch K, Trbusek M. Zemanova J, et al. Among authors: janovska p. Oncotarget. 2016 Sep 20;7(38):62091-62106. doi: 10.18632/oncotarget.11388. Oncotarget. 2016. PMID: 27556692 Free PMC article.
Casein kinase 1 is a therapeutic target in chronic lymphocytic leukemia.
Janovska P, Verner J, Kohoutek J, Bryjova L, Gregorova M, Dzimkova M, Skabrahova H, Radaszkiewicz T, Ovesna P, Vondalova Blanarova O, Nemcova T, Hoferova Z, Vasickova K, Smyckova L, Egle A, Pavlova S, Poppova L, Plevova K, Pospisilova S, Bryja V. Janovska P, et al. Blood. 2018 Mar 15;131(11):1206-1218. doi: 10.1182/blood-2017-05-786947. Epub 2018 Jan 9. Blood. 2018. PMID: 29317454 Free article.
CD20 is dispensable for B-cell receptor signaling but is required for proper actin polymerization, adhesion and migration of malignant B cells.
Kozlova V, Ledererova A, Ladungova A, Peschelova H, Janovska P, Slusarczyk A, Domagala J, Kopcil P, Vakulova V, Oppelt J, Bryja V, Doubek M, Mayer J, Pospisilova S, Smida M. Kozlova V, et al. Among authors: janovska p. PLoS One. 2020 Mar 25;15(3):e0229170. doi: 10.1371/journal.pone.0229170. eCollection 2020. PLoS One. 2020. PMID: 32210425 Free PMC article.
Lyn Phosphorylates and Controls ROR1 Surface Dynamics During Chemotaxis of CLL Cells.
Dave Z, Vondálová Blanářová O, Čada Š, Janovská P, Zezula N, Běhal M, Hanáková K, Ganji SR, Krejci P, Gömöryová K, Peschelová H, Šmída M, Zdráhal Z, Pavlová Š, Kotašková J, Pospíšilová Š, Bryja V. Dave Z, et al. Among authors: janovska p. Front Cell Dev Biol. 2022 Feb 28;10:838871. doi: 10.3389/fcell.2022.838871. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35295854 Free PMC article.
62 results