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Page 1
Discovery of Potent and Exquisitely Selective Inhibitors of Kinase CK1 with Tunable Isoform Selectivity.
Němec V, Khirsariya P, Janovská P, Moyano PM, Maier L, Procházková P, Kebková P, Gybel' T, Berger BT, Chaikuad A, Reinecke M, Kuster B, Knapp S, Bryja V, Paruch K. Němec V, et al. Among authors: khirsariya p. Angew Chem Int Ed Engl. 2023 Mar 6;62(11):e202217532. doi: 10.1002/anie.202217532. Epub 2023 Feb 2. Angew Chem Int Ed Engl. 2023. PMID: 36625768
Pharmacological Mechanism of the Non-hallucinogenic 5-HT2A Agonist Ariadne and Analogs.
Cunningham MJ, Bock HA, Serrano IC, Bechand B, Vidyadhara DJ, Bonniwell EM, Lankri D, Duggan P, Nazarova AL, Cao AB, Calkins MM, Khirsariya P, Hwu C, Katritch V, Chandra SS, McCorvy JD, Sames D. Cunningham MJ, et al. Among authors: khirsariya p. ACS Chem Neurosci. 2023 Jan 4;14(1):119-135. doi: 10.1021/acschemneuro.2c00597. Epub 2022 Dec 15. ACS Chem Neurosci. 2023. PMID: 36521179 Free PMC article.
Cytoprotective activities of kinetin purine isosteres.
Maková B, Mik V, Lišková B, Gonzalez G, Vítek D, Medvedíková M, Monfort B, Ručilová V, Kadlecová A, Khirsariya P, Gándara Barreiro Z, Havlíček L, Zatloukal M, Soural M, Paruch K, D'Autréaux B, Hajdúch M, Strnad M, Voller J. Maková B, et al. Among authors: khirsariya p. Bioorg Med Chem. 2021 Mar 1;33:115993. doi: 10.1016/j.bmc.2021.115993. Epub 2021 Jan 6. Bioorg Med Chem. 2021. PMID: 33497938
The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel-resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe.
Drápela S, Khirsariya P, van Weerden WM, Fedr R, Suchánková T, Búzová D, Červený J, Hampl A, Puhr M, Watson WR, Culig Z, Krejčí L, Paruch K, Souček K. Drápela S, et al. Among authors: khirsariya p. Mol Oncol. 2020 Oct;14(10):2487-2503. doi: 10.1002/1878-0261.12756. Epub 2020 Jul 16. Mol Oncol. 2020. PMID: 32579780 Free PMC article.
Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells.
Boudny M, Zemanova J, Khirsariya P, Borsky M, Verner J, Cerna J, Oltova A, Seda V, Mraz M, Jaros J, Jaskova Z, Spunarova M, Brychtova Y, Soucek K, Drapela S, Kasparkova M, Mayer J, Paruch K, Trbusek M. Boudny M, et al. Among authors: khirsariya p. Haematologica. 2019 Dec;104(12):2443-2455. doi: 10.3324/haematol.2018.203430. Epub 2019 Apr 11. Haematologica. 2019. PMID: 30975914 Free PMC article.
15 results