Liu L - Search Results

1

Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity.

Ramalingam N, Jin SX, Moors TE, Fonseca-Ornelas L, Shimanaka K, Lei S, Cam HP, Watson AH, Brontesi L, Ding L, Hacibaloglu DY, Jiang H, Choi SJ, Kanter E, Liu L, Bartels T, Nuber S, Sulzer D, Mosharov EV, Chen WV, Li S, Selkoe DJ, Dettmer U. Ramalingam N, et al. Among authors: liu l. NPJ Parkinsons Dis. 2023 Jan 16;9(1):4. doi: 10.1038/s41531-023-00444-w. NPJ Parkinsons Dis. 2023. PMID: 36646701 Free PMC article.

2

Decoding the synaptic dysfunction of bioactive human AD brain soluble Aβ to inspire novel therapeutic avenues for Alzheimer's disease.

Li S, Jin M, Liu L, Dang Y, Ostaszewski BL, Selkoe DJ. Li S, et al. Among authors: liu l. Acta Neuropathol Commun. 2018 Nov 8;6(1):121. doi: 10.1186/s40478-018-0626-x. Acta Neuropathol Commun. 2018. PMID: 30409172 Free PMC article.

3

A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor.

Liu L, Ding L, Rovere M, Wolfe MS, Selkoe DJ. Liu L, et al. J Cell Biol. 2019 Feb 4;218(2):644-663. doi: 10.1083/jcb.201806205. Epub 2019 Jan 9. J Cell Biol. 2019. PMID: 30626721 Free PMC article.

4

Verubecestat for Prodromal Alzheimer's Disease.

Li S, Liu L, Selkoe D. Li S, et al. Among authors: liu l. N Engl J Med. 2019 Jul 25;381(4):388. doi: 10.1056/NEJMc1906679. N Engl J Med. 2019. PMID: 31340105 Free PMC article. No abstract available.

5

Multiple BACE1 inhibitors abnormally increase the BACE1 protein level in neurons by prolonging its half-life.

Liu L, Lauro BM, Ding L, Rovere M, Wolfe MS, Selkoe DJ. Liu L, et al. Alzheimers Dement. 2019 Sep;15(9):1183-1194. doi: 10.1016/j.jalz.2019.06.3918. Epub 2019 Aug 12. Alzheimers Dement. 2019. PMID: 31416794 Free PMC article.

6

A novel V272D presenilin mutation associated with logopenia, disorientation, and apraxia in an autosomal-dominant Alzheimer's disease family.

Mengel D, Liu L, Yamamoto R, Zülow S, Deuschl C, Hermann DM, Zerr I, Selkoe DJ, Dodel R. Mengel D, et al. Among authors: liu l. Neurobiol Aging. 2020 Jan;85:154.e5-154.e7. doi: 10.1016/j.neurobiolaging.2019.07.002. Epub 2019 Aug 7. Neurobiol Aging. 2020. PMID: 31500908

7

Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals.

Chhatwal JP, Schultz AP, Dang Y, Ostaszewski B, Liu L, Yang HS, Johnson KA, Sperling RA, Selkoe DJ. Chhatwal JP, et al. Among authors: liu l. Nat Commun. 2020 Nov 27;11(1):6024. doi: 10.1038/s41467-020-19543-w. Nat Commun. 2020. PMID: 33247134 Free PMC article.

8

Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides.

Liu L, Lauro BM, Wolfe MS, Selkoe DJ. Liu L, et al. J Biol Chem. 2021 Jan-Jun;296:100393. doi: 10.1016/j.jbc.2021.100393. Epub 2021 Feb 8. J Biol Chem. 2021. PMID: 33571524 Free PMC article.

9

Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson's disease.

Fonseca-Ornelas L, Viennet T, Rovere M, Jiang H, Liu L, Nuber S, Ericsson M, Arthanari H, Selkoe DJ. Fonseca-Ornelas L, et al. Among authors: liu l. Cell Rep. 2021 Jul 6;36(1):109333. doi: 10.1016/j.celrep.2021.109333. Cell Rep. 2021. PMID: 34233191 Free PMC article.

10

An ultra-sensitive immunoassay detects and quantifies soluble Aβ oligomers in human plasma.

Liu L, Kwak H, Lawton TL, Jin SX, Meunier AL, Dang Y, Ostaszewski B, Pietras AC, Stern AM, Selkoe DJ. Liu L, et al. Alzheimers Dement. 2022 Jun;18(6):1186-1202. doi: 10.1002/alz.12457. Epub 2021 Sep 22. Alzheimers Dement. 2022. PMID: 34550630 Free PMC article.

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