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The NLRP1 and CARD8 inflammasomes detect reductive stress.
Wang Q, Hsiao JC, Yardeny N, Huang HC, O'Mara CM, Orth-He EL, Ball DP, Zhang Z, Bachovchin DA. Wang Q, et al. Among authors: hsiao jc. Cell Rep. 2023 Jan 31;42(1):111966. doi: 10.1016/j.celrep.2022.111966. Epub 2023 Jan 16. Cell Rep. 2023. PMID: 36649710 Free PMC article.
Activation of the CARD8 Inflammasome Requires a Disordered Region.
Chui AJ, Griswold AR, Taabazuing CY, Orth EL, Gai K, Rao SD, Ball DP, Hsiao JC, Bachovchin DA. Chui AJ, et al. Among authors: hsiao jc. Cell Rep. 2020 Oct 13;33(2):108264. doi: 10.1016/j.celrep.2020.108264. Cell Rep. 2020. PMID: 33053349 Free PMC article.
Optimized M24B Aminopeptidase Inhibitors for CARD8 Inflammasome Activation.
Chen Q, Wang A, Covelli DJ, Bhattacharjee A, Wang Q, Orth-He EL, Rao SD, Huang HC, Ball DP, Hsiao JC, Bachovchin DA. Chen Q, et al. Among authors: hsiao jc. J Med Chem. 2023 Feb 23;66(4):2589-2607. doi: 10.1021/acs.jmedchem.2c01535. Epub 2023 Feb 1. J Med Chem. 2023. PMID: 36724486 Free PMC article.
The hydrophobicity of the CARD8 N-terminus tunes inflammasome activation.
Tsamouri LP, Hsiao JC, Wang Q, Geeson MB, Huang HC, Nambiar DR, Zou M, Ball DP, Chui AJ, Bachovchin DA. Tsamouri LP, et al. Among authors: hsiao jc. Cell Chem Biol. 2024 Sep 19;31(9):1699-1713.e8. doi: 10.1016/j.chembiol.2024.06.004. Epub 2024 Jul 10. Cell Chem Biol. 2024. PMID: 38991619
Humoral waning kinetics against SARS-CoV-2 is dictated by disease severity and vaccine platform.
Tong X, Kellman B, Avendano MJ, Mendu M, Hsiao JC, Serrano E, Garcia-Salum T, Muena N, Pardo-Roa C, Morales M, Levican J, Salinas E, Cardenas-Cáceres S, Riquelme A, Tischler ND, Lauffenburger DA, Alter G, McNamara RP, Medina RA. Tong X, et al. Among authors: hsiao jc. medRxiv [Preprint]. 2024 Oct 18:2024.10.17.24315607. doi: 10.1101/2024.10.17.24315607. medRxiv. 2024. PMID: 39484236 Free PMC article. Preprint.
72 results