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Page 1
Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain.
Virtanen AT, Haikarainen T, Sampathkumar P, Palmroth M, Liukkonen S, Liu J, Nekhotiaeva N, Hubbard SR, Silvennoinen O. Virtanen AT, et al. Pharmaceuticals (Basel). 2023 Jan 4;16(1):75. doi: 10.3390/ph16010075. Pharmaceuticals (Basel). 2023. PMID: 36678572 Free PMC article.
New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation.
Arwood ML, Liu Y, Harkins SK, Weinstock DM, Yang L, Stevenson KE, Plana OD, Dong J, Cirka H, Jones KL, Virtanen AT, Gupta DG, Ceas A, Lawney B, Yoda A, Leahy C, Hao M, He Z, Choi HG, Wang Y, Silvennoinen O, Hubbard SR, Zhang T, Gray NS, Li LS. Arwood ML, et al. Among authors: virtanen at. Cell Chem Biol. 2023 Jun 15;30(6):618-631.e12. doi: 10.1016/j.chembiol.2023.05.007. Epub 2023 Jun 7. Cell Chem Biol. 2023. PMID: 37290440 Free PMC article.
Nucleotide-binding mechanisms in pseudokinases.
Hammarén HM, Virtanen AT, Silvennoinen O. Hammarén HM, et al. Among authors: virtanen at. Biosci Rep. 2015 Nov 20;36(1):e00282. doi: 10.1042/BSR20150226. Biosci Rep. 2015. PMID: 26589967 Free PMC article. Review.