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PPAR gamma agonist leriglitazone improves frataxin-loss impairments in cellular and animal models of Friedreich Ataxia.
Rodríguez-Pascau L, Britti E, Calap-Quintana P, Dong YN, Vergara C, Delaspre F, Medina-Carbonero M, Tamarit J, Pallardó FV, Gonzalez-Cabo P, Ros J, Lynch DR, Martinell M, Pizcueta P. Rodríguez-Pascau L, et al. Neurobiol Dis. 2021 Jan;148:105162. doi: 10.1016/j.nbd.2020.105162. Epub 2020 Nov 7. Neurobiol Dis. 2021. PMID: 33171227 Free article.
Safety and efficacy of leriglitazone for preventing disease progression in men with adrenomyeloneuropathy (ADVANCE): a randomised, double-blind, multi-centre, placebo-controlled phase 2-3 trial.
Köhler W, Engelen M, Eichler F, Lachmann R, Fatemi A, Sampson J, Salsano E, Gamez J, Molnar MJ, Pascual S, Rovira M, Vilà A, Pina G, Martín-Ugarte I, Mantilla A, Pizcueta P, Rodríguez-Pascau L, Traver E, Vilalta A, Pascual M, Martinell M, Meya U, Mochel F; ADVANCE Study Group. Köhler W, et al. Among authors: rodriguez pascau l. Lancet Neurol. 2023 Feb;22(2):127-136. doi: 10.1016/S1474-4422(22)00495-1. Lancet Neurol. 2023. PMID: 36681445 Clinical Trial.
Mitochondrial modulation with leriglitazone as a potential treatment for Rett syndrome.
Musokhranova U, Grau C, Vergara C, Rodríguez-Pascau L, Xiol C, Castells AA, Alcántara S, Rodríguez-Pombo P, Pizcueta P, Martinell M, García-Cazorla A, Oyarzábal A. Musokhranova U, et al. Among authors: rodriguez pascau l. J Transl Med. 2023 Oct 26;21(1):756. doi: 10.1186/s12967-023-04622-5. J Transl Med. 2023. PMID: 37884937 Free PMC article.
Cannabidiol ameliorates mitochondrial disease via PPARγ activation in preclinical models.
Puighermanal E, Luna-Sánchez M, Gella A, van der Walt G, Urpi A, Royo M, Tena-Morraja P, Appiah I, de Donato MH, Menardy F, Bianchi P, Esteve-Codina A, Rodríguez-Pascau L, Vergara C, Gómez-Pallarès M, Marsicano G, Bellocchio L, Martinell M, Sanz E, Jurado S, Soriano FX, Pizcueta P, Quintana A. Puighermanal E, et al. Among authors: rodriguez pascau l. Nat Commun. 2024 Sep 4;15(1):7730. doi: 10.1038/s41467-024-51884-8. Nat Commun. 2024. PMID: 39231983 Free PMC article.
Clinical pharmacokinetics of leriglitazone and a translational approach using PBPK modeling to guide the selection of the starting dose in children.
Traver E, Rodríguez-Pascau L, Meya U, Pina G, Pascual S, Poli S, Eckland D, van de Wetering J, Ke A, Lindauer A, Martinell M, Pizcueta P. Traver E, et al. Among authors: rodriguez pascau l. CPT Pharmacometrics Syst Pharmacol. 2024 Jun;13(6):982-993. doi: 10.1002/psp4.13132. Epub 2024 Mar 29. CPT Pharmacometrics Syst Pharmacol. 2024. PMID: 38549500 Free PMC article. Clinical Trial.
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