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Discovery of a novel, highly potent and orally bioavailable pyrrolidinone indole series of irreversible Myeloperoxidase (MPO) inhibitors.
Regard JB, Harrison TJ, Axford J, Axford L, Lee L, Ren X, Deng L, Reynolds A, Mao J, Liu Q, Patnaik A, Cohick E, Hollis-Symynkywicz M, Loi S, Riek S, McKeever U, Dunstan D, Sung M, Ware NF, Brown AP, Hamann LG, Marcinkeviciene J, Patterson AW, Marro ML. Regard JB, et al. Among authors: brown ap. Biochem Pharmacol. 2023 Mar;209:115418. doi: 10.1016/j.bcp.2023.115418. Epub 2023 Jan 21. Biochem Pharmacol. 2023. PMID: 36693437
Correlation Between Nasal Epithelial Injury and In Vitro Cytotoxicity Using a Series of Small Molecule Protein Tyrosine Phosphatase 1B Inhibitors Investigated for Reversal of Leptin Resistance in Obesity.
Brown AP, Saravanan C, Devine P, Magnifico M, Gao J, Beaulieu V, Ma F, Yasoshima K, Barnes-Seeman D, Yamada K. Brown AP, et al. Int J Toxicol. 2017 Jul/Aug;36(4):303-313. doi: 10.1177/1091581817711877. Epub 2017 Jun 8. Int J Toxicol. 2017. PMID: 28592157
Electrophysiological Changes in the Rabbit Ventricular Wedge and Human-Induced Pluripotent Stem-Cell Derived (IPSC) Cardiomyocytes Translate to Severe Arrhythmia Observed in a Canine Toxicology Study, Not Predicted by Standard In Vitro Ion Channel Assays.
Brown AP, Friedrichs GS, Tang HM, Traebert M, Weber V, Yao N, Yan GX. Brown AP, et al. Int J Toxicol. 2024 May-Jun;43(3):231-242. doi: 10.1177/10915818241230900. Epub 2024 Feb 8. Int J Toxicol. 2024. PMID: 38327194
Integrative analyses of convergent adaptation in sympatric extremophile fishes.
Greenway R, De-Kayne R, Brown AP, Camarillo H, Delich C, McGowan KL, Nelson J, Arias-Rodriguez L, Kelley JL, Tobler M. Greenway R, et al. Among authors: brown ap. Curr Biol. 2024 Nov 4;34(21):4968-4982.e7. doi: 10.1016/j.cub.2024.09.027. Epub 2024 Oct 11. Curr Biol. 2024. PMID: 39395416
273 results