Houghton PJ - Search Results

1

Redundant Signaling as the Predominant Mechanism for Resistance to Antibodies Targeting the Type-I Insulin-Like Growth Factor Receptor in Cells Derived from Childhood Sarcoma.

Shackleford TJ, Hariharan S, Vaseva AV, Alagoa K, Espinoza M, Bid HK, Li F, Zhong H, Phelps DA, Roberts RD, Cam H, London CA, Guttridge DC, Chen Y, Rao M, Shiio Y, Houghton PJ. Shackleford TJ, et al. Among authors: houghton pj. Mol Cancer Ther. 2023 Apr 3;22(4):539-550. doi: 10.1158/1535-7163.MCT-20-0625. Mol Cancer Ther. 2023. PMID: 36696581 Free PMC article.

2

Differential regulation of vascular endothelial growth factor by Akt and mammalian target of rapamycin inhibitors in cell lines derived from childhood solid tumors.

Kurmasheva RT, Harwood FC, Houghton PJ. Kurmasheva RT, et al. Among authors: houghton pj. Mol Cancer Ther. 2007 May;6(5):1620-8. doi: 10.1158/1535-7163.MCT-06-0646. Epub 2007 May 4. Mol Cancer Ther. 2007. PMID: 17483438

3

Stage 1 testing and pharmacodynamic evaluation of the HSP90 inhibitor alvespimycin (17-DMAG, KOS-1022) by the pediatric preclinical testing program.

Smith MA, Morton CL, Phelps DA, Kolb EA, Lock R, Carol H, Reynolds CP, Maris JM, Keir ST, Wu J, Houghton PJ. Smith MA, et al. Among authors: houghton pj. Pediatr Blood Cancer. 2008 Jul;51(1):34-41. doi: 10.1002/pbc.21508. Pediatr Blood Cancer. 2008. PMID: 18260120

4

Stage 2 combination testing of rapamycin with cytotoxic agents by the Pediatric Preclinical Testing Program.

Houghton PJ, Morton CL, Gorlick R, Lock RB, Carol H, Reynolds CP, Kang MH, Maris JM, Keir ST, Kolb EA, Wu J, Wozniak AW, Billups CA, Rubinstein L, Smith MA. Houghton PJ, et al. Mol Cancer Ther. 2010 Jan;9(1):101-12. doi: 10.1158/1535-7163.MCT-09-0952. Epub 2010 Jan 6. Mol Cancer Ther. 2010. PMID: 20053767 Free PMC article.

5

mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α.

Cam H, Easton JB, High A, Houghton PJ. Cam H, et al. Among authors: houghton pj. Mol Cell. 2010 Nov 24;40(4):509-20. doi: 10.1016/j.molcel.2010.10.030. Mol Cell. 2010. PMID: 21095582 Free PMC article.

6

Targeting angiogenesis in childhood sarcomas.

Bid HK, Houghton PJ. Bid HK, et al. Among authors: houghton pj. Sarcoma. 2011;2011:601514. doi: 10.1155/2011/601514. Epub 2010 Dec 9. Sarcoma. 2011. PMID: 21197468 Free PMC article.

7

Initial testing (stage 1) of the mTOR kinase inhibitor AZD8055 by the pediatric preclinical testing program.

Houghton PJ, Gorlick R, Kolb EA, Lock R, Carol H, Morton CL, Keir ST, Reynolds CP, Kang MH, Phelps D, Maris JM, Billups C, Smith MA. Houghton PJ, et al. Pediatr Blood Cancer. 2012 Feb;58(2):191-9. doi: 10.1002/pbc.22935. Epub 2011 Feb 18. Pediatr Blood Cancer. 2012. PMID: 21337679 Free PMC article.

8

Regulation of mammalian target of rapamycin complex 1 (mTORC1) by hypoxia: causes and consequences.

Cam H, Houghton PJ. Cam H, et al. Among authors: houghton pj. Target Oncol. 2011 Jun;6(2):95-102. doi: 10.1007/s11523-011-0173-x. Epub 2011 Apr 16. Target Oncol. 2011. PMID: 21499767 Review.

9

Initial testing of the hypoxia-activated prodrug PR-104 by the pediatric preclinical testing program.

Houghton PJ, Lock R, Carol H, Morton CL, Phelps D, Gorlick R, Kolb EA, Keir ST, Reynolds CP, Kang MH, Maris JM, Wozniak AW, Gu Y, Wilson WR, Smith MA. Houghton PJ, et al. Pediatr Blood Cancer. 2011 Sep;57(3):443-53. doi: 10.1002/pbc.22921. Epub 2010 Dec 27. Pediatr Blood Cancer. 2011. PMID: 21744473 Free PMC article.

10

Potent inhibition of angiogenesis by the IGF-1 receptor-targeting antibody SCH717454 is reversed by IGF-2.

Bid HK, Zhan J, Phelps DA, Kurmasheva RT, Houghton PJ. Bid HK, et al. Among authors: houghton pj. Mol Cancer Ther. 2012 Mar;11(3):649-59. doi: 10.1158/1535-7163.MCT-11-0575. Epub 2011 Dec 21. Mol Cancer Ther. 2012. PMID: 22188815 Free PMC article.

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