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Integrating a phenotypic screening with a structural simplification strategy to identify 4-phenoxy-quinoline derivatives to potently disrupt the mitotic localization of Aurora kinase B.
Lv G, Shi Q, Zhang T, Li J, Long Y, Zhang W, Choudhry N, Yang K, Li H, Kalashova J, Yang C, Zhou X, Reddy MC, Anantoju KK, Zhang S, Zhang J, Allen TD, Liu H, Nimishetti N, Yang D. Lv G, et al. Among authors: li j, li h. Bioorg Med Chem. 2023 Feb 15;80:117173. doi: 10.1016/j.bmc.2023.117173. Epub 2023 Jan 16. Bioorg Med Chem. 2023. PMID: 36696874
Discovery and Optimization of Seven-Membered Lactam-Based Compounds to Phenocopy the Inhibition of the Aurora Kinase B.
Huang J, Shi Q, Choudhry N, Li H, Yang C, Kalashova J, Yan Z, Li J, Reddy MC, Gopala SG, Zhang S, Zhang J, Nimishetti N, Yang D. Huang J, et al. Among authors: li j, li h. ACS Med Chem Lett. 2022 Jun 6;13(7):1091-1098. doi: 10.1021/acsmedchemlett.2c00098. eCollection 2022 Jul 14. ACS Med Chem Lett. 2022. PMID: 35859866 Free PMC article.
2-Phenoxy-3, 4'-bipyridine derivatives inhibit AURKB-dependent mitotic processes by disrupting its localization.
Lv G, Shi Q, Zhang T, Li J, Kalashova J, Long Y, Sun Y, Li C, Choudhry N, Li H, Yang C, Zhou X, Reddy MC, Anantoju KK, Jupelli R, Zhang S, Zhang J, Allen T, Liu H, Nimishetti N, Yang D. Lv G, et al. Among authors: li c, li j, li h. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114904. doi: 10.1016/j.ejmech.2022.114904. Epub 2022 Nov 8. Eur J Med Chem. 2023. PMID: 36413818
Orally Bioavailable 4-Phenoxy-quinoline Compound as a Potent Aurora Kinase B Relocation Blocker for Cancer Treatment.
Li J, Zhang T, Shi Q, Lv G, Zhou X, Choudhry N, Kalashova J, Yang C, Li H, Long Y, Sakthivel B, Nimishetti N, Liu H, Allen TD, Zhang J, Yang D. Li J, et al. Among authors: li h. ACS Pharmacol Transl Sci. 2023 Jul 21;6(8):1155-1163. doi: 10.1021/acsptsci.3c00054. eCollection 2023 Aug 11. ACS Pharmacol Transl Sci. 2023. PMID: 37588758 Free PMC article.
Oncogenic Alterations, Race, and Survival in US Veterans with Metastatic Prostate Cancer Undergoing Somatic Tumor Next Generation Sequencing.
Valle LF, Li J, Desai H, Hausler R, Haroldsen C, Chatwal M, Ojo M, Kelley MJ, Rebbeck T, Rose BS, Rettig MB, Nickols NG, Garraway IP, Yamoah K, Maxwell KN. Valle LF, et al. Among authors: li j. bioRxiv [Preprint]. 2024 Oct 25:2024.10.24.620071. doi: 10.1101/2024.10.24.620071. bioRxiv. 2024. PMID: 39484518 Free PMC article. Preprint.
A framework for target discovery in rare cancers.
Li B, Sadagopan A, Li J, Wu Y, Cui Y, Konda P, Weiss CN, Choueiri TK, Doench JG, Viswanathan SR. Li B, et al. Among authors: li j. bioRxiv [Preprint]. 2024 Oct 25:2024.10.24.620074. doi: 10.1101/2024.10.24.620074. bioRxiv. 2024. PMID: 39484513 Free PMC article. Preprint.
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