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Page 1
High-throughput screens identify a lipid nanoparticle that preferentially delivers mRNA to human tumors in vivo.
Huayamares SG, Lokugamage MP, Rab R, Da Silva Sanchez AJ, Kim H, Radmand A, Loughrey D, Lian L, Hou Y, Achyut BR, Ehrhardt A, Hong JS, Sago CD, Paunovska K, Echeverri ES, Vanover D, Santangelo PJ, Sorscher EJ, Dahlman JE. Huayamares SG, et al. Among authors: da silva sanchez aj. J Control Release. 2023 May;357:394-403. doi: 10.1016/j.jconrel.2023.04.005. Epub 2023 Apr 12. J Control Release. 2023. PMID: 37028451 Free PMC article.
Nanoparticle stereochemistry-dependent endocytic processing improves in vivo mRNA delivery.
Hatit MZC, Dobrowolski CN, Lokugamage MP, Loughrey D, Ni H, Zurla C, Da Silva Sanchez AJ, Radmand A, Huayamares SG, Zenhausern R, Paunovska K, Peck HE, Kim J, Sato M, Feldman JI, Rivera MA, Cristian A, Kim Y, Santangelo PJ, Dahlman JE. Hatit MZC, et al. Among authors: da silva sanchez aj. Nat Chem. 2023 Apr;15(4):508-515. doi: 10.1038/s41557-023-01138-9. Epub 2023 Mar 2. Nat Chem. 2023. PMID: 36864143
The Transcriptional Response to Lung-Targeting Lipid Nanoparticles in Vivo.
Radmand A, Lokugamage MP, Kim H, Dobrowolski C, Zenhausern R, Loughrey D, Huayamares SG, Hatit MZC, Ni H, Del Cid A, Da Silva Sanchez AJ, Paunovska K, Schrader Echeverri E, Shajii A, Peck H, Santangelo PJ, Dahlman JE. Radmand A, et al. Among authors: da silva sanchez aj. Nano Lett. 2023 Feb 8;23(3):993-1002. doi: 10.1021/acs.nanolett.2c04479. Epub 2023 Jan 26. Nano Lett. 2023. PMID: 36701517 Free PMC article.
The Extent to Which Lipid Nanoparticles Require Apolipoprotein E and Low-Density Lipoprotein Receptor for Delivery Changes with Ionizable Lipid Structure.
Paunovska K, Da Silva Sanchez AJ, Lokugamage MP, Loughrey D, Echeverri ES, Cristian A, Hatit MZC, Santangelo PJ, Zhao K, Dahlman JE. Paunovska K, et al. Among authors: da silva sanchez aj. Nano Lett. 2022 Dec 28;22(24):10025-10033. doi: 10.1021/acs.nanolett.2c03741. Epub 2022 Dec 15. Nano Lett. 2022. PMID: 36521071
Nanoparticle single-cell multiomic readouts reveal that cell heterogeneity influences lipid nanoparticle-mediated messenger RNA delivery.
Dobrowolski C, Paunovska K, Schrader Echeverri E, Loughrey D, Da Silva Sanchez AJ, Ni H, Hatit MZC, Lokugamage MP, Kuzminich Y, Peck HE, Santangelo PJ, Dahlman JE. Dobrowolski C, et al. Among authors: da silva sanchez aj. Nat Nanotechnol. 2022 Aug;17(8):871-879. doi: 10.1038/s41565-022-01146-9. Epub 2022 Jun 30. Nat Nanotechnol. 2022. PMID: 35768613