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Page 1
The Transcriptional Response to Lung-Targeting Lipid Nanoparticles in Vivo.
Radmand A, Lokugamage MP, Kim H, Dobrowolski C, Zenhausern R, Loughrey D, Huayamares SG, Hatit MZC, Ni H, Del Cid A, Da Silva Sanchez AJ, Paunovska K, Schrader Echeverri E, Shajii A, Peck H, Santangelo PJ, Dahlman JE. Radmand A, et al. Among authors: peck h. Nano Lett. 2023 Feb 8;23(3):993-1002. doi: 10.1021/acs.nanolett.2c04479. Epub 2023 Jan 26. Nano Lett. 2023. PMID: 36701517 Free PMC article.
Aerosol Delivery of Synthetic mRNA to Vaginal Mucosa Leads to Durable Expression of Broadly Neutralizing Antibodies against HIV.
Lindsay KE, Vanover D, Thoresen M, King H, Xiao P, Badial P, Araínga M, Park SB, Tiwari PM, Peck HE, Blanchard EL, Feugang JM, Olivier AK, Zurla C, Villinger F, Woolums AR, Santangelo PJ. Lindsay KE, et al. Among authors: peck he. Mol Ther. 2020 Mar 4;28(3):805-819. doi: 10.1016/j.ymthe.2020.01.002. Epub 2020 Jan 10. Mol Ther. 2020. PMID: 31995741 Free PMC article.
Treatment of influenza and SARS-CoV-2 infections via mRNA-encoded Cas13a in rodents.
Blanchard EL, Vanover D, Bawage SS, Tiwari PM, Rotolo L, Beyersdorf J, Peck HE, Bruno NC, Hincapie R, Michel F, Murray J, Sadhwani H, Vanderheyden B, Finn MG, Brinton MA, Lafontaine ER, Hogan RJ, Zurla C, Santangelo PJ. Blanchard EL, et al. Among authors: peck he. Nat Biotechnol. 2021 Jun;39(6):717-726. doi: 10.1038/s41587-021-00822-w. Epub 2021 Feb 3. Nat Biotechnol. 2021. PMID: 33536629
Species-dependent in vivo mRNA delivery and cellular responses to nanoparticles.
Hatit MZC, Lokugamage MP, Dobrowolski CN, Paunovska K, Ni H, Zhao K, Vanover D, Beyersdorf J, Peck HE, Loughrey D, Sato M, Cristian A, Santangelo PJ, Dahlman JE. Hatit MZC, et al. Among authors: peck he. Nat Nanotechnol. 2022 Mar;17(3):310-318. doi: 10.1038/s41565-021-01030-y. Epub 2022 Feb 7. Nat Nanotechnol. 2022. PMID: 35132167 Free PMC article.
Robust, Durable Gene Activation In Vivo via mRNA-Encoded Activators.
Beyersdorf JP, Bawage S, Iglesias N, Peck HE, Hobbs RA, Wroe JA, Zurla C, Gersbach CA, Santangelo PJ. Beyersdorf JP, et al. ACS Nano. 2022 Apr 26;16(4):5660-5671. doi: 10.1021/acsnano.1c10631. Epub 2022 Mar 31. ACS Nano. 2022. PMID: 35357116 Free PMC article.
Nanoparticle single-cell multiomic readouts reveal that cell heterogeneity influences lipid nanoparticle-mediated messenger RNA delivery.
Dobrowolski C, Paunovska K, Schrader Echeverri E, Loughrey D, Da Silva Sanchez AJ, Ni H, Hatit MZC, Lokugamage MP, Kuzminich Y, Peck HE, Santangelo PJ, Dahlman JE. Dobrowolski C, et al. Among authors: peck he. Nat Nanotechnol. 2022 Aug;17(8):871-879. doi: 10.1038/s41565-022-01146-9. Epub 2022 Jun 30. Nat Nanotechnol. 2022. PMID: 35768613
Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo.
Ni H, Hatit MZC, Zhao K, Loughrey D, Lokugamage MP, Peck HE, Cid AD, Muralidharan A, Kim Y, Santangelo PJ, Dahlman JE. Ni H, et al. Among authors: peck he. Nat Commun. 2022 Aug 15;13(1):4766. doi: 10.1038/s41467-022-32281-5. Nat Commun. 2022. PMID: 35970837 Free PMC article.
Nebulized mRNA-Encoded Antibodies Protect Hamsters from SARS-CoV-2 Infection.
Vanover D, Zurla C, Peck HE, Orr-Burks N, Joo JY, Murray J, Holladay N, Hobbs RA, Jung Y, Chaves LCS, Rotolo L, Lifland AW, Olivier AK, Li D, Saunders KO, Sempowski GD, Crowe JE Jr, Haynes BF, Lafontaine ER, Hogan RJ, Santangelo PJ. Vanover D, et al. Adv Sci (Weinh). 2022 Dec;9(34):e2202771. doi: 10.1002/advs.202202771. Epub 2022 Oct 31. Adv Sci (Weinh). 2022. PMID: 36316224 Free PMC article.
Species-agnostic polymeric formulations for inhalable messenger RNA delivery to the lung.
Rotolo L, Vanover D, Bruno NC, Peck HE, Zurla C, Murray J, Noel RK, O'Farrell L, Araínga M, Orr-Burks N, Joo JY, Chaves LCS, Jung Y, Beyersdorf J, Gumber S, Guerrero-Ferreira R, Cornejo S, Thoresen M, Olivier AK, Kuo KM, Gumbart JC, Woolums AR, Villinger F, Lafontaine ER, Hogan RJ, Finn MG, Santangelo PJ. Rotolo L, et al. Nat Mater. 2023 Mar;22(3):369-379. doi: 10.1038/s41563-022-01404-0. Epub 2022 Nov 28. Nat Mater. 2023. PMID: 36443576
300 results