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A patient-centric modeling framework captures recovery from SARS-CoV-2 infection.
Ruffieux H, Hanson AL, Lodge S, Lawler NG, Whiley L, Gray N, Nolan TH, Bergamaschi L, Mescia F, Turner L, de Sa A, Pelly VS; Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) BioResource COVID-19 Collaboration; Kotagiri P, Kingston N, Bradley JR, Holmes E, Wist J, Nicholson JK, Lyons PA, Smith KGC, Richardson S, Bantug GR, Hess C. Ruffieux H, et al. Among authors: whiley l. Nat Immunol. 2023 Feb;24(2):349-358. doi: 10.1038/s41590-022-01380-2. Epub 2023 Jan 30. Nat Immunol. 2023. PMID: 36717723 Free PMC article.
XCMS-MRM and METLIN-MRM: a cloud library and public resource for targeted analysis of small molecules.
Domingo-Almenara X, Montenegro-Burke JR, Ivanisevic J, Thomas A, Sidibé J, Teav T, Guijas C, Aisporna AE, Rinehart D, Hoang L, Nordström A, Gómez-Romero M, Whiley L, Lewis MR, Nicholson JK, Benton HP, Siuzdak G. Domingo-Almenara X, et al. Among authors: whiley l. Nat Methods. 2018 Sep;15(9):681-684. doi: 10.1038/s41592-018-0110-3. Epub 2018 Aug 27. Nat Methods. 2018. PMID: 30150755 Free PMC article.
Ultrahigh-Performance Liquid Chromatography Tandem Mass Spectrometry with Electrospray Ionization Quantification of Tryptophan Metabolites and Markers of Gut Health in Serum and Plasma-Application to Clinical and Epidemiology Cohorts.
Whiley L, Nye LC, Grant I, Andreas N, Chappell KE, Sarafian MH, Misra R, Plumb RS, Lewis MR, Nicholson JK, Holmes E, Swann JR, Wilson ID. Whiley L, et al. Anal Chem. 2019 Apr 16;91(8):5207-5216. doi: 10.1021/acs.analchem.8b05884. Epub 2019 Mar 25. Anal Chem. 2019. PMID: 30848589 Free PMC article.
Integrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection.
Kimhofer T, Lodge S, Whiley L, Gray N, Loo RL, Lawler NG, Nitschke P, Bong SH, Morrison DL, Begum S, Richards T, Yeap BB, Smith C, Smith KGC, Holmes E, Nicholson JK. Kimhofer T, et al. Among authors: whiley l. J Proteome Res. 2020 Nov 6;19(11):4442-4454. doi: 10.1021/acs.jproteome.0c00519. Epub 2020 Sep 14. J Proteome Res. 2020. PMID: 32806897
Quantitative In-Vitro Diagnostic NMR Spectroscopy for Lipoprotein and Metabolite Measurements in Plasma and Serum: Recommendations for Analytical Artifact Minimization with Special Reference to COVID-19/SARS-CoV-2 Samples.
Loo RL, Lodge S, Kimhofer T, Bong SH, Begum S, Whiley L, Gray N, Lindon JC, Nitschke P, Lawler NG, Schäfer H, Spraul M, Richards T, Nicholson JK, Holmes E. Loo RL, et al. Among authors: whiley l. J Proteome Res. 2020 Nov 6;19(11):4428-4441. doi: 10.1021/acs.jproteome.0c00537. Epub 2020 Oct 16. J Proteome Res. 2020. PMID: 32852212
Urinary metabolic phenotyping for Alzheimer's disease.
Kurbatova N, Garg M, Whiley L, Chekmeneva E, Jiménez B, Gómez-Romero M, Pearce J, Kimhofer T, D'Hondt E, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Aarsland D, Nevado-Holgado A, Liu B, Snowden S, Proitsi P, Ashton NJ, Hye A, Legido-Quigley C, Lewis MR, Nicholson JK, Holmes E, Brazma A, Lovestone S. Kurbatova N, et al. Among authors: whiley l. Sci Rep. 2020 Dec 10;10(1):21745. doi: 10.1038/s41598-020-78031-9. Sci Rep. 2020. PMID: 33303834 Free PMC article.
Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer's disease.
Whiley L, Chappell KE, D'Hondt E, Lewis MR, Jiménez B, Snowden SG, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Swann JR, Hye A, Lovestone S, Legido-Quigley C, Holmes E; AddNeuroMed consortium. Whiley L, et al. Alzheimers Res Ther. 2021 Jan 9;13(1):20. doi: 10.1186/s13195-020-00741-z. Alzheimers Res Ther. 2021. PMID: 33422142 Free PMC article.
A targeted ultra performance liquid chromatography - Tandem mass spectrometric assay for tyrosine and metabolites in urine and plasma: Application to the effects of antibiotics on mice.
Letertre MPM, Myridakis A, Whiley L, Camuzeaux S, Lewis MR, Chappell KE, Thaikkatil A, Dumas ME, Nicholson JK, Swann JR, Wilson ID. Letertre MPM, et al. Among authors: whiley l. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Feb 1;1164:122511. doi: 10.1016/j.jchromb.2020.122511. Epub 2020 Dec 22. J Chromatogr B Analyt Technol Biomed Life Sci. 2021. PMID: 33460909
Systemic Perturbations in Amine and Kynurenine Metabolism Associated with Acute SARS-CoV-2 Infection and Inflammatory Cytokine Responses.
Lawler NG, Gray N, Kimhofer T, Boughton B, Gay M, Yang R, Morillon AC, Chin ST, Ryan M, Begum S, Bong SH, Coudert JD, Edgar D, Raby E, Pettersson S, Richards T, Holmes E, Whiley L, Nicholson JK. Lawler NG, et al. Among authors: whiley l. J Proteome Res. 2021 May 7;20(5):2796-2811. doi: 10.1021/acs.jproteome.1c00052. Epub 2021 Mar 16. J Proteome Res. 2021. PMID: 33724837 Free article.
49 results