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A root cause analysis to identify the mechanistic drivers of immunogenicity against the anti-VEGF biotherapeutic brolucizumab.
Kearns JD, Wassmann P, Olgac U, Fichter M, Christen B, Rubic-Schneider T, Koepke S, Cochin de Billy B, Ledieu D, Andre C, Hawtin S, Fischer B, Moretti F, Hug C, Bepperling A, Brannetti B, Mendez-Garcia C, Littlewood-Evans A, Clemens A, Grosskreutz CL, Mehan P, Schmouder RL, Sasseville V, Brees D, Karle AC. Kearns JD, et al. Among authors: schmouder rl. Sci Transl Med. 2023 Feb;15(681):eabq5068. doi: 10.1126/scitranslmed.abq5068. Epub 2023 Feb 1. Sci Transl Med. 2023. PMID: 36724241
Anti-brolucizumab immune response as one prerequisite for rare retinal vasculitis/retinal vascular occlusion adverse events.
Karle AC, Wrobel MB, Koepke S, Gutknecht M, Gottlieb S, Christen B, Rubic-Schneider T, Pruimboom-Brees I, Leber XC, Scharenberg M, Maciejewski B, Turner O, Saravanan C, Huet F, Littlewood-Evans A, Clemens A, Grosskreutz CL, Kearns JD, Mehan P, Schmouder RL, Sasseville V, Brees D. Karle AC, et al. Among authors: schmouder rl. Sci Transl Med. 2023 Feb;15(681):eabq5241. doi: 10.1126/scitranslmed.abq5241. Epub 2023 Feb 1. Sci Transl Med. 2023. PMID: 36724238
Clinical pharmacokinetics of fingolimod.
David OJ, Kovarik JM, Schmouder RL. David OJ, et al. Among authors: schmouder rl. Clin Pharmacokinet. 2012 Jan 1;51(1):15-28. doi: 10.2165/11596550-000000000-00000. Clin Pharmacokinet. 2012. PMID: 22149256 Review.
Ethnic sensitivity study of fingolimod in white and Asian subjects.
Kovarik JM, Slade A, Voss B, Schmidli H, Riviere GJ, Picard F, Sugita Y, Kawai R, Mee-Lee D, Schmouder RL. Kovarik JM, et al. Among authors: schmouder rl. Int J Clin Pharmacol Ther. 2007 Feb;45(2):98-109. doi: 10.5414/cpp45098. Int J Clin Pharmacol Ther. 2007. PMID: 17323789 Clinical Trial.
36 results