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Page 1
WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma.
Mitchell K, Sprowls SA, Arora S, Shakya S, Silver DJ, Goins CM, Wallace L, Roversi G, Schafer RE, Kay K, Miller TE, Lauko A, Bassett J, Kashyap A, D'Amato Kass J, Mulkearns-Hubert EE, Johnson S, Alvarado J, Rich JN, Holland EC, Paddison PJ, Patel AP, Stauffer SR, Hubert CG, Lathia JD. Mitchell K, et al. Among authors: holland ec. Genes Dev. 2023 Feb 1;37(3-4):86-102. doi: 10.1101/gad.349803.122. Epub 2023 Feb 2. Genes Dev. 2023. PMID: 36732025 Free PMC article.
Functional genomic analysis of adult and pediatric brain tumor isolates.
Hoellerbauer P, Biery MC, Arora S, Rao Y, Girard EJ, Mitchell K, Dighe P, Kufeld M, Kuppers DA, Herman JA, Holland EC, Soroceanu L, Vitanza NA, Olson JM, Pritchard JR, Paddison PJ. Hoellerbauer P, et al. Among authors: holland ec. bioRxiv [Preprint]. 2023 Jan 6:2023.01.05.522885. doi: 10.1101/2023.01.05.522885. bioRxiv. 2023. PMID: 36711964 Free PMC article. Preprint.
Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype.
Nuechterlein N, Shelbourn A, Szulzewsky F, Arora S, Casad M, Pattwell S, Merino-Galan L, Sulman E, Arowa S, Alvinez N, Jung M, Brown D, Tang K, Jackson S, Stoica S, Chittaboina P, Banasavadi-Siddegowda YK, Wirsching HG, Stella N, Shapiro L, Paddison P, Patel AP, Gilbert MR, Abdullaev Z, Aldape K, Pratt D, Holland EC, Cimino PJ. Nuechterlein N, et al. Among authors: holland ec. Genes Dev. 2024 Apr 17;38(5-6):273-288. doi: 10.1101/gad.351350.123. Genes Dev. 2024. PMID: 38589034 Free PMC article.
HOXD12 defines an age-related aggressive subtype of oligodendroglioma.
Nuechterlein N, Cimino S, Shelbourn A, Ha V, Arora S, Rajan S, Shapiro LG, Holland EC, Aldape K, McGranahan T, Gilbert MR, Cimino PJ. Nuechterlein N, et al. Among authors: holland ec. Acta Neuropathol. 2024 Sep 11;148(1):41. doi: 10.1007/s00401-024-02802-1. Acta Neuropathol. 2024. PMID: 39259414 Free PMC article.
Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome.
Thirimanne HN, Almiron-Bonnin D, Nuechterlein N, Arora S, Jensen M, Parada CA, Qiu C, Szulzewsky F, English CW, Chen WC, Sievers P, Nassiri F, Wang JZ, Klisch TJ, Aldape KD, Patel AJ, Cimino PJ, Zadeh G, Sahm F, Raleigh DR, Shendure J, Ferreira M, Holland EC. Thirimanne HN, et al. Among authors: holland ec. Cell Genom. 2024 Jun 12;4(6):100566. doi: 10.1016/j.xgen.2024.100566. Epub 2024 May 23. Cell Genom. 2024. PMID: 38788713 Free PMC article.
Aggressive high-grade NF2 mutant meningiomas downregulate oncogenic YAP signaling via the upregulation of VGLL4 and FAT3/4.
Parrish AG, Arora S, Thirimanne HN, Rudoy D, Schmid S, Sievers P, Sahm F, Holland EC, Szulzewsky F. Parrish AG, et al. Among authors: holland ec. bioRxiv [Preprint]. 2024 May 30:2024.05.30.596719. doi: 10.1101/2024.05.30.596719. bioRxiv. 2024. Update in: Neurooncol Adv. 2024 Aug 24;6(1):vdae148. doi: 10.1093/noajnl/vdae148 PMID: 38854109 Free PMC article. Updated. Preprint.
274 results