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338 results

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Page 1
Phosphoinositide acyl chain saturation drives CD8+ effector T cell signaling and function.
Edwards-Hicks J, Apostolova P, Buescher JM, Maib H, Stanczak MA, Corrado M, Klein Geltink RI, Maccari ME, Villa M, Carrizo GE, Sanin DE, Baixauli F, Kelly B, Curtis JD, Haessler F, Patterson A, Field CS, Caputa G, Kyle RL, Soballa M, Cha M, Paul H, Martin J, Grzes KM, Flachsmann L, Mitterer M, Zhao L, Winkler F, Rafei-Shamsabadi DA, Meiss F, Bengsch B, Zeiser R, Puleston DJ, O'Sullivan D, Pearce EJ, Pearce EL. Edwards-Hicks J, et al. Among authors: winkler f. Nat Immunol. 2023 Mar;24(3):516-530. doi: 10.1038/s41590-023-01419-y. Epub 2023 Feb 2. Nat Immunol. 2023. PMID: 36732424 Free PMC article.
Acetate Promotes T Cell Effector Function during Glucose Restriction.
Qiu J, Villa M, Sanin DE, Buck MD, O'Sullivan D, Ching R, Matsushita M, Grzes KM, Winkler F, Chang CH, Curtis JD, Kyle RL, Van Teijlingen Bakker N, Corrado M, Haessler F, Alfei F, Edwards-Hicks J, Maggi LB Jr, Zehn D, Egawa T, Bengsch B, Klein Geltink RI, Jenuwein T, Pearce EJ, Pearce EL. Qiu J, et al. Among authors: winkler f. Cell Rep. 2019 May 14;27(7):2063-2074.e5. doi: 10.1016/j.celrep.2019.04.022. Cell Rep. 2019. PMID: 31091446 Free PMC article.
Enolase represents a metabolic checkpoint controlling the differential exhaustion programmes of hepatitis virus-specific CD8+ T cells.
Winkler F, Hipp AV, Ramirez C, Martin B, Villa M, Neuwirt E, Gorka O, Aerssens J, Johansson SE, Rana N, Llewellyn-Lacey S, Price DA, Panning M, Groß O, Pearce EL, Hermann CM, Schumann K, Hannibal L, Neumann-Haefelin C, Boettler T, Knolle P, Hofmann M, Wohlleber D, Thimme R, Bengsch B. Winkler F, et al. Gut. 2023 Oct;72(10):1971-1984. doi: 10.1136/gutjnl-2022-328734. Epub 2023 Aug 4. Gut. 2023. PMID: 37541771 Free PMC article.
Efficacy of CTLA-4 checkpoint therapy is dependent on IL-21 signaling to mediate cytotoxic reprogramming of PD-1+CD8+ T cells.
Zhang Z, Langenbach M, Sagar S, Fetsch V, Stritzker J, Severa E, Meng K, Winkler F, Rana N, Zoldan K, Godbole I, Solis S, Weber JS, Rafei-Shamsabadi D, Lehr S, Diehl R, Venhoff AC, Voll RE, Buettner N, Neumann-Haefelin C, Boettler T, Hofmann M, Boerries M, Meiss F, Zeiser R, Thimme R, Herati RS, Bengsch B. Zhang Z, et al. Among authors: winkler f. Nat Immunol. 2025 Jan;26(1):92-104. doi: 10.1038/s41590-024-02027-0. Epub 2024 Dec 19. Nat Immunol. 2025. PMID: 39702858
T-cell exhaustion and residency dynamics inform clinical outcomes in hepatocellular carcinoma.
Barsch M, Salié H, Schlaak AE, Zhang Z, Hess M, Mayer LS, Tauber C, Otto-Mora P, Ohtani T, Nilsson T, Wischer L, Winkler F, Manne S, Rech A, Schmitt-Graeff A, Bronsert P, Hofmann M, Neumann-Haefelin C, Boettler T, Fichtner-Feigl S, van Boemmel F, Berg T, Rimassa L, Di Tommaso L, Saeed A, D'Alessio A, Pinato DJ, Bettinger D, Binder H, John Wherry E, Schultheiss M, Thimme R, Bengsch B. Barsch M, et al. Among authors: winkler f. J Hepatol. 2022 Aug;77(2):397-409. doi: 10.1016/j.jhep.2022.02.032. Epub 2022 Apr 1. J Hepatol. 2022. PMID: 35367533
Differentiating Glioma Recurrence and Pseudoprogression by APTw CEST MRI.
Karimian-Jazi K, Enbergs N, Golubtsov E, Schregel K, Ungermann J, Fels-Palesandro H, Schwarz D, Sturm V, Kernbach JM, Batra D, Ippen FM, Pflüger I, von Knebel Doeberitz N, Heiland S, Bunse L, Platten M, Winkler F, Wick W, Paech D, Bendszus M, Breckwoldt MO. Karimian-Jazi K, et al. Among authors: winkler f. Invest Radiol. 2024 Dec 9. doi: 10.1097/RLI.0000000000001145. Online ahead of print. Invest Radiol. 2024. PMID: 39644107
Spatio-temporal transcriptomics of chromothriptic SHH-medulloblastoma identifies multiple genetic clones that resist treatment and drive relapse.
Kats I, Simovic-Lorenz M, Schreiber HS, Sant P, Mallm JP, Körber V, Li A, Velmurugan P, Heuer S, Kües L, Devens F, Sill M, Jugold M, Moustafa M, Abdollahi A, Winkler F, Korshunov A, Pfister SM, Stegle O, Ernst A. Kats I, et al. Among authors: winkler f. Nat Commun. 2024 Nov 29;15(1):10370. doi: 10.1038/s41467-024-54709-w. Nat Commun. 2024. PMID: 39609432 Free PMC article.
Monocyte subsets in breast cancer patients under treatment with aromatase inhibitor and mucin-1 cancer vaccine.
Knöbl V, Maier L, Grasl S, Kratzer C, Winkler F, Eder V, Hayden H, Sahagun Cortez MA, Sachet M, Oehler R, Frantal S, Fesl C, Zehetner K, Pfeiler G, Bartsch R, Fitzal F, Singer CF, Filipits M, Gnant M, Brostjan C. Knöbl V, et al. Among authors: winkler f. J Transl Med. 2024 Oct 8;22(1):913. doi: 10.1186/s12967-024-05659-w. J Transl Med. 2024. PMID: 39380101 Free PMC article.
338 results