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LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein.
Shilts J, Crozier TWM, Teixeira-Silva A, Gabaev I, Gerber PP, Greenwood EJD, Watson SJ, Ortmann BM, Gawden-Bone CM, Pauzaite T, Hoffmann M, Nathan JA, Pöhlmann S, Matheson NJ, Lehner PJ, Wright GJ. Shilts J, et al. Among authors: pohlmann s. PLoS Biol. 2023 Feb 3;21(2):e3001959. doi: 10.1371/journal.pbio.3001959. eCollection 2023 Feb. PLoS Biol. 2023. PMID: 36735681 Free PMC article.
The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies.
Gierer S, Bertram S, Kaup F, Wrensch F, Heurich A, Krämer-Kühl A, Welsch K, Winkler M, Meyer B, Drosten C, Dittmer U, von Hahn T, Simmons G, Hofmann H, Pöhlmann S. Gierer S, et al. Among authors: pohlmann s. J Virol. 2013 May;87(10):5502-11. doi: 10.1128/JVI.00128-13. Epub 2013 Mar 6. J Virol. 2013. PMID: 23468491 Free PMC article.
Inhibition of proprotein convertases abrogates processing of the middle eastern respiratory syndrome coronavirus spike protein in infected cells but does not reduce viral infectivity.
Gierer S, Müller MA, Heurich A, Ritz D, Springstein BL, Karsten CB, Schendzielorz A, Gnirß K, Drosten C, Pöhlmann S. Gierer S, et al. Among authors: pohlmann s. J Infect Dis. 2015 Mar 15;211(6):889-97. doi: 10.1093/infdis/jiu407. Epub 2014 Jul 23. J Infect Dis. 2015. PMID: 25057042 Free PMC article.
The Tetherin Antagonism of the Ebola Virus Glycoprotein Requires an Intact Receptor-Binding Domain and Can Be Blocked by GP1-Specific Antibodies.
Brinkmann C, Nehlmeier I, Walendy-Gnirß K, Nehls J, González Hernández M, Hoffmann M, Qiu X, Takada A, Schindler M, Pöhlmann S. Brinkmann C, et al. Among authors: pohlmann s. J Virol. 2016 Nov 28;90(24):11075-11086. doi: 10.1128/JVI.01563-16. Print 2016 Dec 15. J Virol. 2016. PMID: 27707924 Free PMC article.
329 results