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The outcome of boosting mitochondrial activity in alcohol-associated liver disease is organ-dependent.
Goikoetxea-Usandizaga N, Bravo M, Egia-Mendikute L, Abecia L, Serrano-Maciá M, Urdinguio RG, Clos-García M, Rodríguez-Agudo R, Araujo-Legido R, López-Bermudo L, Delgado TC, Lachiondo-Ortega S, González-Recio I, Gil-Pitarch C, Peña-Cearra A, Simón J, Benedé-Ubieto R, Ariño S, Herranz JM, Azkargorta M, Salazar-Bermeo J, Martí N, Varela-Rey M, Falcón-Pérez JM, Lorenzo Ó, Nogueiras R, Elortza F, Nevzorova YA, Cubero FJ, Saura D, Martínez-Cruz LA, Sabio G, Palazón A, Sancho-Bru P, Elguezabal N, Fraga MF, Ávila MA, Bataller R, Marín JJG, Martín F, Martínez-Chantar ML. Goikoetxea-Usandizaga N, et al. Among authors: nevzorova ya. Hepatology. 2023 Sep 1;78(3):878-895. doi: 10.1097/HEP.0000000000000303. Epub 2023 Feb 9. Hepatology. 2023. PMID: 36745935 Free PMC article.
The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-β signaling.
Borkham-Kamphorst E, Schaffrath C, Van de Leur E, Haas U, Tihaa L, Meurer SK, Nevzorova YA, Liedtke C, Weiskirchen R. Borkham-Kamphorst E, et al. Among authors: nevzorova ya. Biochim Biophys Acta. 2014 May;1843(5):902-14. doi: 10.1016/j.bbamcr.2014.01.023. Epub 2014 Jan 31. Biochim Biophys Acta. 2014. PMID: 24487063 Free article.
TNFR1 determines progression of chronic liver injury in the IKKγ/Nemo genetic model.
Cubero FJ, Singh A, Borkham-Kamphorst E, Nevzorova YA, Al Masaoudi M, Haas U, Boekschoten MV, Gassler N, Weiskirchen R, Muller M, Liedtke C, Trautwein C. Cubero FJ, et al. Among authors: nevzorova ya. Cell Death Differ. 2013 Nov;20(11):1580-92. doi: 10.1038/cdd.2013.112. Epub 2013 Aug 9. Cell Death Differ. 2013. PMID: 23933814 Free PMC article.
Haematopoietic cell-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury.
Cubero FJ, Zhao G, Nevzorova YA, Hatting M, Al Masaoudi M, Verdier J, Peng J, Schaefer FM, Hermanns N, Boekschoten MV, Grouls C, Gassler N, Kiessling F, Muller M, Davis RJ, Liedtke C, Trautwein C. Cubero FJ, et al. Among authors: nevzorova ya. J Hepatol. 2015 Jan;62(1):140-9. doi: 10.1016/j.jhep.2014.08.029. Epub 2014 Aug 27. J Hepatol. 2015. PMID: 25173965
56 results