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Synthetic genetic circuits to uncover and enforce the OCT4 trajectories of successful reprogramming of human fibroblasts.
Ilia K, Shakiba N, Bingham T, Jones RD, Kaminski MM, Aravera E, Bruno S, Palacios S, Weiss R, Collins JJ, Del Vecchio D, Schlaeger TM. Ilia K, et al. Among authors: schlaeger tm. bioRxiv [Preprint]. 2023 Jan 25:2023.01.25.525529. doi: 10.1101/2023.01.25.525529. bioRxiv. 2023. Update in: Sci Adv. 2023 Dec;9(48):eadg8495. doi: 10.1126/sciadv.adg8495 PMID: 36747813 Free PMC article. Updated. Preprint.
Astrocyte-Derived Exosomes Regulate Sperm miR-34c Levels to Mediate the Transgenerational Effects of Paternal Chronic Social Instability Stress.
Champroux A, Sadat-Shirazi M, Chen X, Hacker J, Yang Y, Feig LA. Champroux A, et al. bioRxiv [Preprint]. 2024 Sep 10:2023.04.21.537854. doi: 10.1101/2023.04.21.537854. bioRxiv. 2024. Update in: Epigenetics. 2024 Dec;19(1):2346694. doi: 10.1080/15592294.2024.2346694 PMID: 37786715 Free PMC article. Updated. Preprint.
Transmission of reduced levels of miR-34/449 from sperm to preimplantation embryos is a key step in the transgenerational epigenetic inheritance of the effects of paternal chronic social instability stress.
Champroux A, Tang Y, Dickson DA, Meng A, Harrington A, Liaw L, Marzi M, Nicassio F, Schlaeger TM, Feig LA. Champroux A, et al. Among authors: schlaeger tm. Epigenetics. 2024 Dec;19(1):2346694. doi: 10.1080/15592294.2024.2346694. Epub 2024 May 13. Epigenetics. 2024. PMID: 38739481 Free PMC article.
Maturation and persistence of CAR T cells derived from human pluripotent stem cells via chemical inhibition of G9a/GLP.
Jing R, Falchetti M, Han T, Najia M, Hensch LT, Meader E, Lummertz da Rocha E, Kononov M, Wang S, Bingham T, Li Z, Zhao Y, Frenis K, Kubaczka C, Yang S, Jha D, Rodrigues-Luiz GF, Rowe RG, Schlaeger TM, Maus MV, North TE, Zon LI, Daley GQ. Jing R, et al. Among authors: schlaeger tm. Cell Stem Cell. 2024 Nov 5:S1934-5909(24)00366-7. doi: 10.1016/j.stem.2024.10.004. Online ahead of print. Cell Stem Cell. 2024. PMID: 39504968
A conserved transcription factor regulatory program promotes tendon fate.
Niu X, Melendez DL, Raj S, Cai J, Senadeera D, Mandelbaum J, Shestopalov IA, Martin SD, Zon LI, Schlaeger TM, Lai LP, McMahon AP, Craft AM, Galloway JL. Niu X, et al. Among authors: schlaeger tm. Dev Cell. 2024 Dec 2;59(23):3106-3123.e12. doi: 10.1016/j.devcel.2024.08.006. Epub 2024 Aug 30. Dev Cell. 2024. PMID: 39216481
WNT signalling control by KDM5C during development affects cognition.
Karwacki-Neisius V, Jang A, Cukuroglu E, Tai A, Jiao A, Predes D, Yoon J, Brookes E, Chen J, Iberg A, Halbritter F, Õunap K, Gecz J, Schlaeger TM, Ho Sui S, Göke J, He X, Lehtinen MK, Pomeroy SL, Shi Y. Karwacki-Neisius V, et al. Among authors: schlaeger tm. Nature. 2024 Mar;627(8004):594-603. doi: 10.1038/s41586-024-07067-y. Epub 2024 Feb 21. Nature. 2024. PMID: 38383780 Free PMC article.
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