Brear P - Search Results

1

Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.

Nain-Perez A, Nilsson O, Lulla A, Håversen L, Brear P, Liljenberg S, Hyvönen M, Borén J, Grøtli M. Nain-Perez A, et al. Among authors: brear p. Eur J Med Chem. 2023 Mar 15;250:115177. doi: 10.1016/j.ejmech.2023.115177. Epub 2023 Feb 1. Eur J Med Chem. 2023. PMID: 36753880 Free article.

2

Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases.

Brear P, Telford J, Taylor GL, Westwood NJ. Brear P, et al. Chembiochem. 2012 Nov 5;13(16):2374-83. doi: 10.1002/cbic.201200433. Epub 2012 Oct 15. Chembiochem. 2012. PMID: 23070966

3

From Data Mining of Chitinophaga sp. Genome to Enzyme Discovery of a Hyperthermophilic Metallocarboxypeptidase.

Fernandes GC, Sierra EGM, Brear P, Pereira MR, Lemos EGM. Fernandes GC, et al. Among authors: brear p. Microorganisms. 2021 Feb 14;9(2):393. doi: 10.3390/microorganisms9020393. Microorganisms. 2021. PMID: 33673011 Free PMC article.

4

Specific inhibition of CK2α from an anchor outside the active site.

Brear P, De Fusco C, Hadje Georgiou K, Francis-Newton NJ, Stubbs CJ, Sore HF, Venkitaraman AR, Abell C, Spring DR, Hyvönen M. Brear P, et al. Chem Sci. 2016 Nov 1;7(11):6839-6845. doi: 10.1039/c6sc02335e. Epub 2016 Jul 12. Chem Sci. 2016. PMID: 28451126 Free PMC article.

5

A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066.

De Fusco C, Brear P, Iegre J, Georgiou KH, Sore HF, Hyvönen M, Spring DR. De Fusco C, et al. Among authors: brear p. Bioorg Med Chem. 2017 Jul 1;25(13):3471-3482. doi: 10.1016/j.bmc.2017.04.037. Epub 2017 Apr 30. Bioorg Med Chem. 2017. PMID: 28495381 Free PMC article.

6

Second-generation CK2α inhibitors targeting the αD pocket.

Iegre J, Brear P, De Fusco C, Yoshida M, Mitchell SL, Rossmann M, Carro L, Sore HF, Hyvönen M, Spring DR. Iegre J, et al. Among authors: brear p. Chem Sci. 2018 Feb 20;9(11):3041-3049. doi: 10.1039/c7sc05122k. eCollection 2018 Mar 21. Chem Sci. 2018. PMID: 29732088 Free PMC article.

7

Novel non-ATP competitive small molecules targeting the CK2 α/β interface.

Brear P, North A, Iegre J, Hadje Georgiou K, Lubin A, Carro L, Green W, Sore HF, Hyvönen M, Spring DR. Brear P, et al. Bioorg Med Chem. 2018 Jul 15;26(11):3016-3020. doi: 10.1016/j.bmc.2018.05.011. Epub 2018 May 9. Bioorg Med Chem. 2018. PMID: 29759799 Free PMC article.

8

Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein-protein interaction.

Iegre J, Brear P, Baker DJ, Tan YS, Atkinson EL, Sore HF, O' Donovan DH, Verma CS, Hyvönen M, Spring DR. Iegre J, et al. Among authors: brear p. Chem Sci. 2019 Apr 12;10(19):5056-5063. doi: 10.1039/c9sc00798a. eCollection 2019 May 21. Chem Sci. 2019. PMID: 31183056 Free PMC article.

9

Evolutionary plasticity in the allosteric regulator-binding site of pyruvate kinase isoform PykA from Pseudomonas aeruginosa.

Abdelhamid Y, Brear P, Greenhalgh J, Chee X, Rahman T, Welch M. Abdelhamid Y, et al. Among authors: brear p. J Biol Chem. 2019 Oct 18;294(42):15505-15516. doi: 10.1074/jbc.RA119.009156. Epub 2019 Sep 4. J Biol Chem. 2019. PMID: 31484721 Free PMC article.

10

Targeting of Fumarate Hydratase from Mycobacterium tuberculosis Using Allosteric Inhibitors with a Dimeric-Binding Mode.

Whitehouse AJ, Libardo MDJ, Kasbekar M, Brear PD, Fischer G, Thomas CJ, Barry CE 3rd, Boshoff HIM, Coyne AG, Abell C. Whitehouse AJ, et al. J Med Chem. 2019 Dec 12;62(23):10586-10604. doi: 10.1021/acs.jmedchem.9b01203. Epub 2019 Sep 27. J Med Chem. 2019. PMID: 31517489 Free PMC article.

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