Dou X - Search Results

1

The structure-based optimization of 3-substituted indolin-2-one derivatives as potent and isoform-selective c-Jun N-terminal kinase 3 (JNK3) inhibitors and biological evaluation.

Li Z, Zhu G, Liu X, Gao T, Fang F, Dou X, Li Y, Zheng R, Jin H, Zhang L, Liu Z, Zhang L. Li Z, et al. Among authors: dou x. Eur J Med Chem. 2023 Mar 15;250:115167. doi: 10.1016/j.ejmech.2023.115167. Epub 2023 Feb 3. Eur J Med Chem. 2023. PMID: 36764123

2

Discovery of new GSK-3β inhibitors through structure-based virtual screening.

Dou X, Jiang L, Wang Y, Jin H, Liu Z, Zhang L. Dou X, et al. Bioorg Med Chem Lett. 2018 Jan 15;28(2):160-166. doi: 10.1016/j.bmcl.2017.11.036. Epub 2017 Nov 24. Bioorg Med Chem Lett. 2018. PMID: 29208522

3

Unravel a neuroactive sHA sulfation pattern with neurogenesis activity by a library of defined oligosaccharides.

Yao W, Chen M, Dou X, Jin H, Zhang X, Zhu Y, Sha M, Liu Z, Meng X, Zhang L, Zhu S, Li Z. Yao W, et al. Among authors: dou x. Eur J Med Chem. 2019 Feb 1;163:583-596. doi: 10.1016/j.ejmech.2018.12.004. Epub 2018 Dec 4. Eur J Med Chem. 2019. PMID: 30557831

4

Discovery of novel glycogen synthase kinase-3α inhibitors: Structure-based virtual screening, preliminary SAR and biological evaluation for treatment of acute myeloid leukemia.

Wang Y, Dou X, Jiang L, Jin H, Zhang L, Zhang L, Liu Z. Wang Y, et al. Among authors: dou x. Eur J Med Chem. 2019 Jun 1;171:221-234. doi: 10.1016/j.ejmech.2019.03.039. Epub 2019 Mar 20. Eur J Med Chem. 2019. PMID: 30925338

5

Multistage Screening Reveals 3-Substituted Indolin-2-one Derivatives as Novel and Isoform-Selective c-Jun N-terminal Kinase 3 (JNK3) Inhibitors: Implications to Drug Discovery for Potential Treatment of Neurodegenerative Diseases.

Dou X, Huang H, Li Y, Jiang L, Wang Y, Jin H, Jiao N, Zhang L, Zhang L, Liu Z. Dou X, et al. J Med Chem. 2019 Jul 25;62(14):6645-6664. doi: 10.1021/acs.jmedchem.9b00537. Epub 2019 Jul 15. J Med Chem. 2019. PMID: 31268308

6

Engineering a bacterial sialyltransferase for di-sialylation of a therapeutic antibody.

Wang M, Wang Y, Liu K, Dou X, Liu Z, Zhang L, Ye XS. Wang M, et al. Among authors: dou x. Org Biomol Chem. 2020 Apr 15;18(15):2886-2892. doi: 10.1039/d0ob00276c. Org Biomol Chem. 2020. PMID: 32236230

7

Rational modification, synthesis and biological evaluation of 3,4-dihydroquinoxalin-2(1H)-one derivatives as potent and selective c-Jun N-terminal kinase 3 (JNK3) inhibitors.

Dou X, Huang H, Jiang L, Zhu G, Jin H, Jiao N, Zhang L, Liu Z, Zhang L. Dou X, et al. Eur J Med Chem. 2020 Sep 1;201:112445. doi: 10.1016/j.ejmech.2020.112445. Epub 2020 Jun 26. Eur J Med Chem. 2020. PMID: 32603981

8

Discovery of novel ataxia telangiectasia mutated (ATM) kinase modulators: Computational simulation, biological evaluation and cancer combinational chemotherapy study.

Dou X, Sun X, Huang H, Jiang L, Jin Z, Liu Y, Zou Y, Li Z, Zhu G, Jin H, Jiao N, Zhang L, Liu Z, Zhang L. Dou X, et al. Eur J Med Chem. 2022 Apr 5;233:114196. doi: 10.1016/j.ejmech.2022.114196. Epub 2022 Feb 23. Eur J Med Chem. 2022. PMID: 35231830

9

Discovery of 2-(furan-2-ylmethylene)hydrazine-1-carbothioamide derivatives as novel inhibitors of SARS-CoV-2 main protease.

Dou X, Sun Q, Xu G, Liu Y, Zhang C, Wang B, Lu Y, Guo Z, Su L, Huo T, Zhao X, Wang C, Yu Z, Song S, Zhang L, Liu Z, Lai L, Jiao N. Dou X, et al. Eur J Med Chem. 2022 Aug 5;238:114508. doi: 10.1016/j.ejmech.2022.114508. Epub 2022 Jun 3. Eur J Med Chem. 2022. PMID: 35688005 Free PMC article.

10

Discovery of 3-oxo-1,2,3,4-tetrahydropyrido[1,2-a]pyrazin derivatives as SARS-CoV-2 main protease inhibitors through virtual screening and biological evaluation.

Dou X, Sun Q, Liu Y, Lu Y, Zhang C, Xu G, Xu Y, Huo T, Zhao X, Su L, Xing Y, Lai L, Jiao N. Dou X, et al. Bioorg Med Chem Lett. 2024 Jan 1;97:129547. doi: 10.1016/j.bmcl.2023.129547. Epub 2023 Nov 8. Bioorg Med Chem Lett. 2024. PMID: 37944867

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