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Page 1
Phenyl Dihydrouracil: An Alternative Cereblon Binder for PROTAC Design.
Jarusiewicz JA, Yoshimura S, Mayasundari A, Actis M, Aggarwal A, McGowan K, Yang L, Li Y, Fu X, Mishra V, Heath R, Narina S, Pruett-Miller SM, Nishiguchi G, Yang JJ, Rankovic Z. Jarusiewicz JA, et al. Among authors: aggarwal a. ACS Med Chem Lett. 2023 Jan 4;14(2):141-145. doi: 10.1021/acsmedchemlett.2c00436. eCollection 2023 Feb 9. ACS Med Chem Lett. 2023. PMID: 36793425 Free PMC article.
Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines.
Nishiguchi G, Mascibroda LG, Young SM, Caine EA, Abdelhamed S, Kooijman JJ, Miller DJ, Das S, McGowan K, Mayasundari A, Shi Z, Barajas JM, Hiltenbrand R, Aggarwal A, Chang Y, Mishra V, Narina S, Thomas M, Loughran AJ, Kalathur R, Yu K, Zhou S, Wang X, High AA, Peng J, Pruett-Miller SM, Daniels DL, Urh M, Shelat AA, Mullighan CG, Riching KM, Zaman GJR, Fischer M, Klco JM, Rankovic Z. Nishiguchi G, et al. Among authors: aggarwal a. Nat Commun. 2024 Jan 16;15(1):482. doi: 10.1038/s41467-024-44698-1. Nat Commun. 2024. PMID: 38228616 Free PMC article.
Structure-Activity Relationship of Potent, Selective, and Orally Bioavailable Molecular Glue Degraders of CK1α.
Nishiguchi G, Caine EA, McGowan K, Shi Z, Aggarwal A, Mayasundari A, Price J, Yang L, Li Y, Fu X, Mascibroda LG, Das S, Daniels DL, Urh M, Klco JM, Riching KM, Rankovic Z. Nishiguchi G, et al. Among authors: aggarwal a. ACS Med Chem Lett. 2024 Sep 12;15(10):1692-1698. doi: 10.1021/acsmedchemlett.4c00250. eCollection 2024 Oct 10. ACS Med Chem Lett. 2024. PMID: 39411539 Free PMC article.
Structural basis of BAK activation in mitochondrial apoptosis initiation.
Singh G, Guibao CD, Seetharaman J, Aggarwal A, Grace CR, McNamara DE, Vaithiyalingam S, Waddell MB, Moldoveanu T. Singh G, et al. Among authors: aggarwal a. Nat Commun. 2022 Jan 11;13(1):250. doi: 10.1038/s41467-021-27851-y. Nat Commun. 2022. PMID: 35017502 Free PMC article.
Multipronged strategy for protection and motivation of healthcare workers during the COVID-19 pandemic: a real-life study.
Premkumar M, Dutta U, Sandhu A, Kaur H, Singh MP, Goyal K, Guru RR, Lakshmi P, Gupta M, Biswal M, Ghosh A, Sachan A, Guleria S, Sahoo S, Grover S, Gupta T, Koushal V, Devnani M, Talati S, Mohindra R, Suri V, Ratho RK, Bhalla A, Jain S, Arora P, Pandey N, Kumar A, Aggarwal AK, Chakrabarti A, Puri GD, Ram J, Pandav SS, Sehgal R, Malhotra P, Yaddanapuddi N, Singh S; PGIMER COVID-19 Healthcare Worker Welfare Taskforce. Premkumar M, et al. Among authors: aggarwal ak. Antimicrob Steward Healthc Epidemiol. 2024 Jul 25;4(1):e101. doi: 10.1017/ash.2023.459. eCollection 2024. Antimicrob Steward Healthc Epidemiol. 2024. PMID: 39823119 Free PMC article.
Safety and Outcomes of an On-Demand Transfusion Strategy Versus Prophylactic Transfusion of Platelets in Patients With Liver Cirrhosis and Severe Thrombocytopenia Undergoing High-Risk Procedures: A Post Hoc Analysis of Two Randomized Controlled Trials.
Biswas S, Gupta S, Mehta S, Swaroop S, Aggarwal A, Agarwal A, Saxena S, Sehgal T, Aggarwal S, Gunjan D, Nayak B, Gamanagatti S, Shalimar. Biswas S, et al. Among authors: aggarwal a. J Clin Exp Hepatol. 2025 May-Jun;15(3):102467. doi: 10.1016/j.jceh.2024.102467. Epub 2024 Nov 30. J Clin Exp Hepatol. 2025. PMID: 39822652
Effect of Characteristic Inflammatory and Structural Pelvic Magnetic Resonance Imaging Lesions on Expert Assessment of Axial Juvenile Spondyloarthritis.
Mayer A, Brandon TG, Aggarwal A, Burgos-Vargas R, Colbert RA, Horneff G, Joos R, Laxer RM, Minden K, Ravelli A, Ruperto N, Smith JA, Stoll ML, Tse SM, Van den Bosch F, Maksymowych WP, Lambert RG, Biko DM, Chauvin NA, Francavilla ML, Jaremko JL, Herregods N, Kasapcopur O, Yildiz M, Srinivasalu H, Faerber JA, Naden R, Hendry AM, Weiss PF. Mayer A, et al. Among authors: aggarwal a. J Rheumatol. 2025 Jan 15:jrheum.2024-0696. doi: 10.3899/jrheum.2024-0696. Online ahead of print. J Rheumatol. 2025. PMID: 39814440
Evaluation of Cereblon-Directing Warheads for the Development of Orally Bioavailable PROTACs.
Actis M, Cresser-Brown J, Caine EA, Steger M, Aggarwal A, Mayasundari A, Murphy N, Valinciute G, Li Y, Fu X, Yang L, Marsh G, Hughes G, Karadogan B, Wheeler D, Norley M, Spain F, Urh M, Roussel MF, Schwalb B, Daub H, Riching KM, Maple H, Nishiguchi G, Rankovic Z. Actis M, et al. Among authors: aggarwal a. J Med Chem. 2025 Jan 15. doi: 10.1021/acs.jmedchem.4c02709. Online ahead of print. J Med Chem. 2025. PMID: 39813384
3,715 results