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Page 1
Phenyl Dihydrouracil: An Alternative Cereblon Binder for PROTAC Design.
Jarusiewicz JA, Yoshimura S, Mayasundari A, Actis M, Aggarwal A, McGowan K, Yang L, Li Y, Fu X, Mishra V, Heath R, Narina S, Pruett-Miller SM, Nishiguchi G, Yang JJ, Rankovic Z. Jarusiewicz JA, et al. Among authors: mcgowan k. ACS Med Chem Lett. 2023 Jan 4;14(2):141-145. doi: 10.1021/acsmedchemlett.2c00436. eCollection 2023 Feb 9. ACS Med Chem Lett. 2023. PMID: 36793425 Free PMC article.
Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators.
Nishiguchi G, Keramatnia F, Min J, Chang Y, Jonchere B, Das S, Actis M, Price J, Chepyala D, Young B, McGowan K, Slavish PJ, Mayasundari A, Jarusiewicz JA, Yang L, Li Y, Fu X, Garrett SH, Papizan JB, Kodali K, Peng J, Pruett Miller SM, Roussel MF, Mullighan C, Fischer M, Rankovic Z. Nishiguchi G, et al. Among authors: mcgowan k. J Med Chem. 2021 Jun 10;64(11):7296-7311. doi: 10.1021/acs.jmedchem.0c01313. Epub 2021 May 27. J Med Chem. 2021. PMID: 34042448 Free PMC article.
VU6010608, a Novel mGlu7 NAM from a Series of N-(2-(1H-1,2,4-Triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamides.
Reed CW, McGowan KM, Spearing PK, Stansley BJ, Roenfanz HF, Engers DW, Rodriguez AL, Engelberg EM, Luscombe VB, Loch MT, Remke DH, Rook JM, Blobaum AL, Conn PJ, Niswender CM, Lindsley CW. Reed CW, et al. Among authors: mcgowan km. ACS Med Chem Lett. 2017 Nov 8;8(12):1326-1330. doi: 10.1021/acsmedchemlett.7b00429. eCollection 2017 Dec 14. ACS Med Chem Lett. 2017. PMID: 29259756 Free PMC article.
Ligand-based virtual screen for the discovery of novel M5 inhibitor chemotypes.
Geanes AR, Cho HP, Nance KD, McGowan KM, Conn PJ, Jones CK, Meiler J, Lindsley CW. Geanes AR, et al. Among authors: mcgowan km. Bioorg Med Chem Lett. 2016 Sep 15;26(18):4487-4491. doi: 10.1016/j.bmcl.2016.07.071. Epub 2016 Jul 30. Bioorg Med Chem Lett. 2016. PMID: 27503678 Free PMC article.
Continuous collective analysis of chemical reactions.
Hu M, Yang L, Twarog N, Ochoada J, Li Y, Vrettos EI, Torres-Hernandez AX, Martinez JB, Bhatia J, Young BM, Price J, McGowan K, Nguyen TH, Shi Z, Anyanwu M, Rimmer MA, Mercer S, Rankovic Z, Shelat AA, Blair DJ. Hu M, et al. Among authors: mcgowan k. Nature. 2024 Dec;636(8042):374-379. doi: 10.1038/s41586-024-08211-4. Epub 2024 Dec 11. Nature. 2024. PMID: 39663496
333 results