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Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19.
Unoh Y, Uehara S, Nakahara K, Nobori H, Yamatsu Y, Yamamoto S, Maruyama Y, Taoda Y, Kasamatsu K, Suto T, Kouki K, Nakahashi A, Kawashima S, Sanaki T, Toba S, Uemura K, Mizutare T, Ando S, Sasaki M, Orba Y, Sawa H, Sato A, Sato T, Kato T, Tachibana Y. Unoh Y, et al. Among authors: uehara s. J Med Chem. 2022 May 12;65(9):6499-6512. doi: 10.1021/acs.jmedchem.2c00117. Epub 2022 Mar 30. J Med Chem. 2022. PMID: 35352927 Free PMC article.
Macrocyclic Peptides as a Novel Class of NNMT Inhibitors: A SAR Study Aimed at Inhibitory Activity in the Cell.
Hayashi K, Uehara S, Yamamoto S, Cary DR, Nishikawa J, Ueda T, Ozasa H, Mihara K, Yoshimura N, Kawai T, Ono T, Yamamoto S, Fumoto M, Mikamiyama H. Hayashi K, et al. Among authors: uehara s. ACS Med Chem Lett. 2021 Jun 2;12(7):1093-1101. doi: 10.1021/acsmedchemlett.1c00134. eCollection 2021 Jul 8. ACS Med Chem Lett. 2021. PMID: 34267879 Free PMC article.
Identification of cap-dependent endonuclease inhibitors with broad-spectrum activity against bunyaviruses.
Toba S, Sato A, Kawai M, Taoda Y, Unoh Y, Kusakabe S, Nobori H, Uehara S, Uemura K, Taniguchi K, Kobayashi M, Noshi T, Yoshida R, Naito A, Shishido T, Maruyama J, Paessler S, Carr MJ, Hall WW, Yoshimatsu K, Arikawa J, Matsuno K, Sakoda Y, Sasaki M, Orba Y, Sawa H, Kida H. Toba S, et al. Among authors: uehara s. Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2206104119. doi: 10.1073/pnas.2206104119. Epub 2022 Aug 29. Proc Natl Acad Sci U S A. 2022. PMID: 36037386 Free PMC article.
Bcl‑xL‑specific BH3 mimetic A‑1331852 suppresses proliferation of fluorouracil‑resistant colorectal cancer cells by inducing apoptosis.
Kato A, Takahashi H, Asai H, Uehara S, Harata S, Fujii Y, Watanabe K, Yanagita T, Suzuki T, Ushigome H, Shiga K, Yamakawa Y, Ogawa R, Mitsui A, Matsuo Y, Takiguchi S. Kato A, et al. Among authors: uehara s. Oncol Rep. 2025 Feb;53(2):26. doi: 10.3892/or.2024.8859. Epub 2024 Dec 24. Oncol Rep. 2025. PMID: 39717947
1,088 results