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Elephant TP53-RETROGENE 9 induces transcription-independent apoptosis at the mitochondria.
Preston AJ, Rogers A, Sharp M, Mitchell G, Toruno C, Barney BB, Donovan LN, Bly J, Kennington R, Payne E, Iovino A, Furukawa G, Robinson R, Shamloo B, Buccilli M, Anders R, Eckstein S, Fedak EA, Wright T, Maley CC, Kiso WK, Schmitt D, Malkin D, Schiffman JD, Abegglen LM. Preston AJ, et al. Among authors: malkin d. Cell Death Discov. 2023 Feb 16;9(1):66. doi: 10.1038/s41420-023-01348-7. Cell Death Discov. 2023. PMID: 36797268 Free PMC article.
Precision oncology for children: A primer for paediatricians.
Cohen-Gogo S, Denburg AE, Villani A, Thacker N, Egan G, Simao Rafael M, Malkin D, Morgenstern DA. Cohen-Gogo S, et al. Among authors: malkin d. Paediatr Child Health. 2023 Mar 21;28(5):278-284. doi: 10.1093/pch/pxac123. eCollection 2023 Aug. Paediatr Child Health. 2023. PMID: 37484033 Free PMC article.
Hopes, concerns, satisfaction and regret in a precision medicine trial for childhood cancer: a mixed-methods study of parent and patient perspectives.
Wakefield CE, Hetherington K, Robertson EG, Donoghoe MW, Hunter JD, Vetsch J, Marron JM, Tucker KM, Marshall GM, Broom A, Haber M, Tyrrell V, Malkin D, Lau L, Mateos MK, O'Brien TA, Ziegler DS. Wakefield CE, et al. Among authors: malkin d. Br J Cancer. 2023 Nov;129(10):1634-1644. doi: 10.1038/s41416-023-02429-1. Epub 2023 Sep 19. Br J Cancer. 2023. PMID: 37726477 Free PMC article.
The landscape of primary mismatch repair deficient gliomas in children, adolescents, and young adults: a multi-cohort study.
Negm L, Chung J, Nobre L, Bennett J, Fernandez NR, Nunes NM, Liu ZA, Komosa M, Aronson M, Zhang C, Stengs L, Bianchi V, Edwards M, Doherty S, Ercan AB, Cardenas MF, Macias M, Lueder MR, Ku M, Johnson M, Chang Y, Dimayacyac JR, Kraya AA, Guo Y, Naky S, Keith J, Gao AF, Munoz DG, Nguyen L, Tsang DS, Lim-Fat MJ, Das S, Shlien A, Ramaswamy V, Huang A, Malkin D, Villani A, Ertl-Wagner B, Levine A, Robinson GW, Pollock BH, Spector LG, Sei S, Dirks PB, Getz G, Nichols KE, Resnick AC, Wheeler DA, Das A, Maruvka YE, Hawkins C, Tabori U. Negm L, et al. Among authors: malkin d. Lancet Oncol. 2025 Jan;26(1):123-135. doi: 10.1016/S1470-2045(24)00640-5. Epub 2024 Dec 16. Lancet Oncol. 2025. PMID: 39701117
tp53 R217H and R242H mutant zebrafish exhibit dysfunctional p53 hallmarks and recapitulate Li-Fraumeni syndrome phenotypes.
Kobar K, Tuzi L, Fiene JA, Burnley E, Galpin KJC, Midgen C, Laverty B, Subasri V, Wen TT, Hirst M, Moksa M, Carles A, Cao Q, Shlien A, Malkin D, Prykhozhij SV, Berman JN. Kobar K, et al. Among authors: malkin d. Biochim Biophys Acta Mol Basis Dis. 2024 Dec 4;1871(3):167612. doi: 10.1016/j.bbadis.2024.167612. Online ahead of print. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 39643218 Free article.
Clustering of TP53 variants into functional classes correlates with cancer risk and identifies different phenotypes of Li-Fraumeni syndrome.
Montellier E, Lemonnier N, Penkert J, Freycon C, Blanchet S, Amadou A, Chuffart F, Fischer NW, Achatz MI, Levine AJ, Goudie C, Malkin D, Bougeard G, Kratz CP, Hainaut P. Montellier E, et al. Among authors: malkin d. iScience. 2024 Nov 1;27(12):111296. doi: 10.1016/j.isci.2024.111296. eCollection 2024 Dec 20. iScience. 2024. PMID: 39634561 Free PMC article.
Update on cancer screening in children with syndromes of bone lesions, hereditary leiomyoma and renal cell carcinoma syndrome, and other rare syndromes.
Michaeli O, Kim SY, Mitchell SG, Jongmans MCJ, Wasserman JD, Perrino MR, Das A, MacFarland SP, Scollon SR, Greer MC, Sobreira N, Gallinger B, Lupo PJ, Malkin D, Schneider KW, Schultz KAP, Foulkes WD, Woodward ER, Stewart DR. Michaeli O, et al. Among authors: malkin d. Clin Cancer Res. 2024 Nov 27. doi: 10.1158/1078-0432.CCR-24-2171. Online ahead of print. Clin Cancer Res. 2024. PMID: 39601780
380 results