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The TAS1R2 sweet taste receptor regulates skeletal muscle mass and fitness.
Serrano J, Boyd J, Mason C, Smith KR, Karolyi K, Kondo S, Brown IS, Maurya SK, Meshram NN, Serna V, Gilger J, Branch DA, Gardell SJ, Baskin KK, Ayala JE, Pratley RE, Goodpaster BH, Coen PM, Kyriazis GA. Serrano J, et al. Among authors: kyriazis ga. Res Sq [Preprint]. 2023 Feb 9:rs.3.rs-2475555. doi: 10.21203/rs.3.rs-2475555/v1. Res Sq. 2023. PMID: 36798161 Free PMC article. Preprint.
A partial loss-of-function variant (Ile191Val) of the TAS1R2 glucose receptor is associated with enhanced responses to exercise training in older adults with obesity: A translational study.
Serrano J, Kondo S, Link GM, Brown IS, Pratley RE, Baskin KK, Goodpaster BH, Coen PM, Kyriazis GA. Serrano J, et al. Among authors: kyriazis ga. Metabolism. 2025 Jan;162:156045. doi: 10.1016/j.metabol.2024.156045. Epub 2024 Oct 10. Metabolism. 2025. PMID: 39393515 Free PMC article.
The Ile191Val is a partial loss-of-function variant of the TAS1R2 sweet-taste receptor and is associated with reduced glucose excursions in humans.
Serrano J, Seflova J, Park J, Pribadi M, Sanematsu K, Shigemura N, Serna V, Yi F, Mari A, Procko E, Pratley RE, Robia SL, Kyriazis GA. Serrano J, et al. Among authors: kyriazis ga. Mol Metab. 2021 Dec;54:101339. doi: 10.1016/j.molmet.2021.101339. Epub 2021 Sep 9. Mol Metab. 2021. PMID: 34509698 Free PMC article.
High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice.
Serrano J, Smith KR, Crouch AL, Sharma V, Yi F, Vargova V, LaMoia TE, Dupont LM, Serna V, Tang F, Gomes-Dias L, Blakeslee JJ, Hatzakis E, Peterson SN, Anderson M, Pratley RE, Kyriazis GA. Serrano J, et al. Among authors: kyriazis ga. Microbiome. 2021 Jan 12;9(1):11. doi: 10.1186/s40168-020-00976-w. Microbiome. 2021. PMID: 33431052 Free PMC article. Clinical Trial.
NIH Workshop Report: sensory nutrition and disease.
Reed DR, Alhadeff AL, Beauchamp GK, Chaudhari N, Duffy VB, Dus M, Fontanini A, Glendinning JI, Green BG, Joseph PV, Kyriazis GA, Lyte M, Maruvada P, McGann JP, McLaughlin JT, Moran TH, Murphy C, Noble EE, Pepino MY, Pluznick JL, Rother KI, Saez E, Spector AC, Sternini C, Mattes RD. Reed DR, et al. Among authors: kyriazis ga. Am J Clin Nutr. 2021 Jan 4;113(1):232-245. doi: 10.1093/ajcn/nqaa302. Am J Clin Nutr. 2021. PMID: 33300030 Free PMC article.
T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways.
Smith K, Karimian Azari E, LaMoia TE, Hussain T, Vargova V, Karolyi K, Veldhuis PP, Arnoletti JP, de la Fuente SG, Pratley RE, Osborne TF, Kyriazis GA. Smith K, et al. Among authors: kyriazis ga. Mol Metab. 2018 Nov;17:98-111. doi: 10.1016/j.molmet.2018.08.009. Epub 2018 Aug 27. Mol Metab. 2018. PMID: 30201274 Free PMC article.
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