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MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state.
You SF, Brase L, Filipello F, Iyer AK, Del-Aguila J, He J, D'Oliveira Albanus R, Budde J, Norton J, Gentsch J, Dräger NM, Sattler SM, Kampmann M, Piccio L, Morris JC, Perrin RJ, McDade E; Dominantly Inherited Alzheimer Network; Paul SM, Cashikar AG, Benitez BA, Harari O, Karch CM. You SF, et al. Among authors: morris jc. medRxiv [Preprint]. 2023 Feb 8:2023.02.06.23285545. doi: 10.1101/2023.02.06.23285545. medRxiv. 2023. PMID: 36798226 Free PMC article. Preprint.
Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and informs causal proteins for Alzheimer's disease.
Cruchaga C, Western D, Timsina J, Wang L, Wang C, Yang C, Ali M, Beric A, Gorijala P, Kohlfeld P, Budde J, Levey A, Morris J, Perrin R, Ruiz A, Marquié M, Boada M, de Rojas I, Rutledge J, Oh H, Wilson E, Guen YL, Alvarez I, Aguilar M, Greicius M, Pastor P, Pulford D, Ibanez L, Wyss-Coray T, Sung YJ, Phillips B. Cruchaga C, et al. Res Sq [Preprint]. 2023 Jun 9:rs.3.rs-2814616. doi: 10.21203/rs.3.rs-2814616/v1. Res Sq. 2023. Update in: Nat Genet. 2024 Dec;56(12):2672-2684. doi: 10.1038/s41588-024-01972-8 PMID: 37333337 Free PMC article. Updated. Preprint.
Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson's disease.
Phillips B, Western D, Wang L, Timsina J, Sun Y, Gorijala P, Yang C, Do A, Nykänen NP, Alvarez I, Aguilar M, Pastor P, Morris JC, Schindler SE, Fagan AM, Puerta R, García-González P, de Rojas I, Marquié M, Boada M, Ruiz A, Perlmutter JS; Dominantly Inherited Alzheimer Network (DIAN) Consortia; Ibanez L, Perrin RJ, Sung YJ, Cruchaga C. Phillips B, et al. Among authors: morris jc. NPJ Parkinsons Dis. 2023 Jul 8;9(1):107. doi: 10.1038/s41531-023-00555-4. NPJ Parkinsons Dis. 2023. PMID: 37422510 Free PMC article.
Novel CSF tau biomarkers can be used for disease staging of sporadic Alzheimer's disease.
Salvadó G, Horie K, Barthélemy NR, Vogel JW, Binette AP, Chen CD, Aschenbrenner AJ, Gordon BA, Benzinger TLS, Holtzman DM, Morris JC, Palmqvist S, Stomrud E, Janelidze S, Ossenkoppele R, Schindler SE, Bateman RJ, Hansson O. Salvadó G, et al. Among authors: morris jc. medRxiv [Preprint]. 2023 Jul 16:2023.07.14.23292650. doi: 10.1101/2023.07.14.23292650. medRxiv. 2023. PMID: 37503281 Free PMC article. Preprint.
Increasing hub disruption parallels dementia severity in autosomal dominant Alzheimer disease.
Tu JC, Millar PR, Strain JF, Eck A, Adeyemo B, Daniels A, Karch C, Huey ED, McDade E, Day GS, Yakushev I, Hassenstab J, Morris J, Llibre-Guerra JJ, Ibanez L, Jucker M, Mendez PC, Bateman RJ, Perrin RJ, Benzinger T, Jack CR Jr, Betzel R, Ances BM, Eggebrecht AT, Gordon BA, Wheelock MD; Dominantly Inherited Alzheimer Network. Tu JC, et al. Among authors: morris j. bioRxiv [Preprint]. 2023 Nov 1:2023.10.29.564633. doi: 10.1101/2023.10.29.564633. bioRxiv. 2023. PMID: 37961586 Free PMC article. Preprint.
Cell-free RNA signatures predict Alzheimer's disease.
Cisterna-García A, Beric A, Ali M, Pardo JA, Chen HH, Fernandez MV, Norton J, Gentsch J, Bergmann K, Budde J, Perlmutter JS, Morris JC, Cruchaga C, Botia JA, Ibanez L. Cisterna-García A, et al. Among authors: morris jc. iScience. 2023 Nov 23;26(12):108534. doi: 10.1016/j.isci.2023.108534. eCollection 2023 Dec 15. iScience. 2023. PMID: 38089583 Free PMC article.
Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease.
Millar PR, Gordon BA, Wisch JK, Schultz SA, Benzinger TL, Cruchaga C, Hassenstab JJ, Ibanez L, Karch C, Llibre-Guerra JJ, Morris JC, Perrin RJ, Supnet-Bell C, Xiong C, Allegri RF, Berman SB, Chhatwal JP, Chrem Mendez PA, Day GS, Hofmann A, Ikeuchi T, Jucker M, Lee JH, Levin J, Lopera F, Niimi Y, Sánchez-González VJ, Schofield PR, Sosa-Ortiz AL, Vöglein J; Dominantly Inherited Alzheimer Network; Bateman RJ, Ances BM, McDade EM. Millar PR, et al. Among authors: morris jc. Mol Neurodegener. 2023 Dec 19;18(1):98. doi: 10.1186/s13024-023-00688-3. Mol Neurodegener. 2023. PMID: 38111006 Free PMC article.
Benchmarking of a multi-biomarker low-volume panel for Alzheimer's Disease and related dementia research.
Ibanez L, Liu M, Beric A, Timsina J, Kholfeld P, Bergmann K, Lowery J, Sykora N, Sanchez-Montejo B, Brock W, Budde JP, Bateman RJ, Barthelemy N, Schindler SE, Holtzman DM, Benzinger TLS, Xiong C, Tarawneh R, Moulder K, Morris JC, Sung YJ, Cruchaga C. Ibanez L, et al. Among authors: morris jc. medRxiv [Preprint]. 2024 Jun 14:2024.06.13.24308895. doi: 10.1101/2024.06.13.24308895. medRxiv. 2024. Update in: Alzheimers Dement. 2024 Nov 22. doi: 10.1002/alz.14413 PMID: 38947090 Free PMC article. Updated. Preprint.
A genetic and proteomic comparison of key AD biomarkers across tissues.
Marsh TW, Western D, Timsina J, Gorijala P, Yang C, Pastor P, Liu M, Morris JC, Bateman RJ, Schindler SE, Sung YJ; Dominantly Inherited Alzheimer Network; Cruchaga C. Marsh TW, et al. Among authors: morris jc. Alzheimers Dement. 2024 Sep;20(9):6423-6440. doi: 10.1002/alz.14139. Epub 2024 Jul 30. Alzheimers Dement. 2024. PMID: 39077866 Free PMC article.
Evolution of white matter hyperintensity segmentation methods and implementation over the past two decades; an incomplete shift towards deep learning.
Rahmani M, Dierker D, Yaeger L, Saykin A, Luckett PH, Vlassenko AG, Owens C, Jafri H, Womack K, Fripp J, Xia Y, Tosun D, Benzinger TLS, Masters CL, Lee JM, Morris JC, Goyal MS, Strain JF; ADOPIC, ADNI Investigators; Kukull W, Weiner M; Biostats, Database and Bioinformatics; Burnham S, CoxDoecke TJ, Fedyashov V, Fripp J, Shishegar R, Xiong C, Marcus D, Raniga P, Li S; Cognition; Aschenbrenner A, Hassenstab J, Lim YY, Maruff P, Sohrabi H, Robertson J, Markovic S; Imaging; Bourgeat P, Doré V, Mayo CJ, Mussoumzadeh P, Rowe C, Villemagne V; CSF and Blood; Bateman R, Fowler C, Li QX, Martins R, Schindler S, Shaw L; Genetics; Cruchaga C, Harari O, Laws S, Porter T, O'Brien E; Neuropathology; Perrin R; NACC; Kukull W; DIAN; Bateman R, McDade E; Cerebrovascular Disease (CVD) Risk; Jack C, Morris J, Yassi N; Hippocampal Sclerosis (HS-TDP43) Risk; Bourgeat P, Perrin R, Roberts B, Villemagne V; Artificial Intelligence and Machine Learning; Fedyashov V, Goudey B. Rahmani M, et al. Among authors: morris j, morris jc. Brain Imaging Behav. 2024 Oct;18(5):1310-1322. doi: 10.1007/s11682-024-00902-w. Epub 2024 Jul 31. Brain Imaging Behav. 2024. PMID: 39083144 Free PMC article. Review.
1,703 results