Yuan K - Search Results

1

Discovery of Potent DYRK2 Inhibitors with High Selectivity, Great Solubility, and Excellent Safety Properties for the Treatment of Prostate Cancer.

Yuan K, Shen H, Zheng M, Xia F, Li Q, Chen W, Ji M, Yang H, Zhuang X, Cai Z, Min W, Wang X, Xiao Y, Yang P. Yuan K, et al. J Med Chem. 2023 Mar 23;66(6):4215-4230. doi: 10.1021/acs.jmedchem.3c00106. Epub 2023 Feb 17. J Med Chem. 2023. PMID: 36800260

2

Computational discovery and biological evaluation of novel inhibitors targeting histone-lysine N-methyltransferase SET7.

Min W, Hou Z, Zhang F, Xie S, Yuan K, Dong H, Wang L, Qi L, Luo C, Ding H, Yang P. Min W, et al. Among authors: yuan k. Bioorg Med Chem. 2020 Apr 1;28(7):115372. doi: 10.1016/j.bmc.2020.115372. Epub 2020 Feb 13. Bioorg Med Chem. 2020. PMID: 32088124

3

Discovery of novel and selective CDK4/6 inhibitors by pharmacophore and structure-based virtual screening.

Yuan K, Min W, Wang X, Li J, Kuang W, Zhang F, Xie S, Yang P. Yuan K, et al. Future Med Chem. 2020 Jun;12(12):1121-1136. doi: 10.4155/fmc-2020-0011. Epub 2020 May 13. Future Med Chem. 2020. PMID: 32400188

4

Selective inhibition of CDK4/6: A safe and effective strategy for developing anticancer drugs.

Yuan K, Wang X, Dong H, Min W, Hao H, Yang P. Yuan K, et al. Acta Pharm Sin B. 2021 Jan;11(1):30-54. doi: 10.1016/j.apsb.2020.05.001. Epub 2020 May 23. Acta Pharm Sin B. 2021. PMID: 33532179 Free PMC article. Review.

5

Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives to reduce SREBPs expression for the treatment of hyperlipidemia.

Ge H, Zhang W, Yuan K, Xue H, Cheng H, Chen W, Xie Y, Zhang J, Xu X, Yang P. Ge H, et al. Among authors: yuan k. Eur J Med Chem. 2021 Oct 5;221:113522. doi: 10.1016/j.ejmech.2021.113522. Epub 2021 May 5. Eur J Med Chem. 2021. PMID: 33984804

6

Computational discovery, structural optimization and biological evaluation of novel inhibitors targeting transient receptor potential vanilloid type 3 (TRPV3).

Zhang F, Lin Y, Min W, Hou Y, Yuan K, Wang J, Yang P. Zhang F, et al. Among authors: yuan k. Bioorg Chem. 2021 Sep;114:105093. doi: 10.1016/j.bioorg.2021.105093. Epub 2021 Jun 13. Bioorg Chem. 2021. PMID: 34182309

7

Design, Synthesis, and Biological Evaluation of Icaritin Derivatives as Novel Putative DEPTOR Inhibitors for Multiple Myeloma Treatment.

Hou Y, Kuang W, Min W, Liu Z, Zhang F, Yuan K, Wang X, Sun C, Cheng H, Wang L, Xiao Y, Pu S, Xin GZ, Yang P. Hou Y, et al. Among authors: yuan k. J Med Chem. 2021 Oct 28;64(20):14942-14954. doi: 10.1021/acs.jmedchem.1c00087. Epub 2021 Oct 13. J Med Chem. 2021. PMID: 34644502

8

Discovery of novel and orally bioavailable CDK 4/6 inhibitors with high kinome selectivity, low toxicity and long-acting stability for the treatment of multiple myeloma.

Yuan K, Kuang W, Chen W, Ji M, Min W, Zhu Y, Hou Y, Wang X, Li J, Wang L, Yang P. Yuan K, et al. Eur J Med Chem. 2022 Jan 15;228:114024. doi: 10.1016/j.ejmech.2021.114024. Epub 2021 Nov 29. Eur J Med Chem. 2022. PMID: 34875521

9

Corrigendum to "Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives to reduce SREBPs expression for the treatment of hyperlipidemia" [Eur. J. Med. Chem. 221 (2021) 113522].

Ge H, Zhang W, Yuan K, Xue H, Cheng H, Chen W, Xie Y, Zhang J, Xu X, Yang P. Ge H, et al. Among authors: yuan k. Eur J Med Chem. 2022 Jan 15;228:114041. doi: 10.1016/j.ejmech.2021.114041. Epub 2021 Dec 10. Eur J Med Chem. 2022. PMID: 34902733 No abstract available.

10

Discovery of Dual CDK6/PIM1 Inhibitors with a Novel Structure, High Potency, and Favorable Druggability for the Treatment of Acute Myeloid Leukemia.

Yuan K, Ji M, Xie S, Qiu Z, Chen W, Min W, Xia F, Zheng M, Wang X, Li J, Hou Y, Kuang W, Wang L, Gu W, Li Z, Yang P. Yuan K, et al. J Med Chem. 2022 Jan 13;65(1):857-875. doi: 10.1021/acs.jmedchem.1c02019. Epub 2021 Dec 27. J Med Chem. 2022. PMID: 34958208

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