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Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance.
Fazakerley DJ, van Gerwen J, Cooke KC, Duan X, Needham EJ, Díaz-Vegas A, Madsen S, Norris DM, Shun-Shion AS, Krycer JR, Burchfield JG, Yang P, Wade MR, Brozinick JT, James DE, Humphrey SJ. Fazakerley DJ, et al. Among authors: krycer jr. Nat Commun. 2023 Feb 18;14(1):923. doi: 10.1038/s41467-023-36549-2. Nat Commun. 2023. PMID: 36808134 Free PMC article.
Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo.
Kleinert M, Sylow L, Fazakerley DJ, Krycer JR, Thomas KC, Oxbøll AJ, Jordy AB, Jensen TE, Yang G, Schjerling P, Kiens B, James DE, Ruegg MA, Richter EA. Kleinert M, et al. Among authors: krycer jr. Mol Metab. 2014 Jun 27;3(6):630-41. doi: 10.1016/j.molmet.2014.06.004. eCollection 2014 Sep. Mol Metab. 2014. PMID: 25161886 Free PMC article.
SnapShot: Insulin/IGF1 Signaling.
Ma DK, Stolte C, Krycer JR, James DE, O'Donoghue SI. Ma DK, et al. Among authors: krycer jr. Cell. 2015 May 7;161(4):948-948.e1. doi: 10.1016/j.cell.2015.04.041. Cell. 2015. PMID: 25957692 Free article.
Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumor Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in Adipocytes.
Fazakerley DJ, Naghiloo S, Chaudhuri R, Koumanov F, Burchfield JG, Thomas KC, Krycer JR, Prior MJ, Parker BL, Murrow BA, Stöckli J, Meoli CC, Holman GD, James DE. Fazakerley DJ, et al. Among authors: krycer jr. J Biol Chem. 2015 Sep 25;290(39):23528-42. doi: 10.1074/jbc.M115.657361. Epub 2015 Aug 3. J Biol Chem. 2015. PMID: 26240143 Free PMC article.
Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling Pathway.
Trefely S, Khoo PS, Krycer JR, Chaudhuri R, Fazakerley DJ, Parker BL, Sultani G, Lee J, Stephan JP, Torres E, Jung K, Kuijl C, James DE, Junutula JR, Stöckli J. Trefely S, et al. Among authors: krycer jr. J Biol Chem. 2015 Oct 23;290(43):25834-46. doi: 10.1074/jbc.M115.658815. Epub 2015 Sep 4. J Biol Chem. 2015. PMID: 26342081 Free PMC article.
mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3.
Kleinert M, Parker BL, Chaudhuri R, Fazakerley DJ, Serup A, Thomas KC, Krycer JR, Sylow L, Fritzen AM, Hoffman NJ, Jeppesen J, Schjerling P, Ruegg MA, Kiens B, James DE, Richter EA. Kleinert M, et al. Among authors: krycer jr. Mol Metab. 2016 Jun 22;5(8):646-655. doi: 10.1016/j.molmet.2016.06.007. eCollection 2016 Aug. Mol Metab. 2016. PMID: 27656402 Free PMC article.
14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function.
Schoenwaelder SM, Darbousset R, Cranmer SL, Ramshaw HS, Orive SL, Sturgeon S, Yuan Y, Yao Y, Krycer JR, Woodcock J, Maclean J, Pitson S, Zheng Z, Henstridge DC, van der Wal D, Gardiner EE, Berndt MC, Andrews RK, James DE, Lopez AF, Jackson SP. Schoenwaelder SM, et al. Among authors: krycer jr. Nat Commun. 2016 Sep 27;7:12862. doi: 10.1038/ncomms12862. Nat Commun. 2016. PMID: 27670677 Free PMC article.
61 results