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Oncogenic Kras G12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8 + T cells dependent manner.
Mahadevan KK, McAndrews KM, LeBleu VS, Yang S, Lyu H, Li B, Sockwell AM, Kirtley ML, Morse SJ, Moreno Diaz BA, Kim MP, Feng N, Lopez AM, Guerrero PA, Sugimoto H, Arian KA, Ying H, Barekatain Y, Kelly PJ, Maitra A, Heffernan TP, Kalluri R. Mahadevan KK, et al. Among authors: ying h. bioRxiv [Preprint]. 2023 Feb 18:2023.02.15.528757. doi: 10.1101/2023.02.15.528757. bioRxiv. 2023. PMID: 36824971 Free PMC article. Preprint.
Therapeutic targeting of Syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers.
Takeda M, Theardy MS, Sorokin A, Coker O, Kanikarla P, Chen S, Yang Z, Nguyen P, Wei Y, Yao J, Wang X, Yan L, Jin Y, Cai Y, Paku M, Chen Z, Li KZ, Citron F, Tomihara H, Gao S, Deem AK, Zhao J, Wang H, Hanash S, DePinho RA, Maitra A, Draetta GF, Ying H, Kopetz S, Yao W. Takeda M, et al. Among authors: ying h. bioRxiv [Preprint]. 2024 Aug 8:2024.08.06.606865. doi: 10.1101/2024.08.06.606865. bioRxiv. 2024. PMID: 39211217 Free PMC article. Preprint.
All-trans retinoic acid-mediated ADAR1 degradation synergizes with PD-1 blockade to suppress pancreatic cancer.
Li CF, Bai LY, Wei Y, Lee HH, Yang R, Yao J, Wang H, Wang YN, Chang WC, Shen YC, Wang SC, Chou CW, Fu J, Ling J, Chu YY, Chiu CF, Wang M, Yu D, Chiao PJ, Liang H, Maitra A, Ying H, Hung MC. Li CF, et al. Among authors: ying h. bioRxiv [Preprint]. 2024 Oct 23:2024.10.20.619300. doi: 10.1101/2024.10.20.619300. bioRxiv. 2024. PMID: 39484589 Free PMC article. Preprint.
KRAS inhibition activates an actionable CD24 'don't eat me' signal in pancreas cancer.
Wei Y, Liu M, Yen EY, Yao J, Nguyen PT, Wang X, Yang Z, Yousef A, Pan D, Jin Y, Theady MS, Park J, Cai Y, Takeda M, Vasquez M, Zhou Y, Zhao H, Viale A, Wang H, Zhao D, DePinho RA, Yao W, Ying H. Wei Y, et al. Among authors: ying h. bioRxiv [Preprint]. 2023 Sep 23:2023.09.21.558891. doi: 10.1101/2023.09.21.558891. bioRxiv. 2023. PMID: 37790498 Free PMC article. Preprint.
Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance.
Li F, Wang Y, Hwang I, Jang JY, Xu L, Deng Z, Yu EY, Cai Y, Wu C, Han Z, Huang YH, Huang X, Zhang L, Yao J, Lue NF, Lieberman PM, Ying H, Paik J, Zheng H. Li F, et al. Among authors: ying h. bioRxiv [Preprint]. 2023 Feb 11:2023.02.10.528023. doi: 10.1101/2023.02.10.528023. bioRxiv. 2023. Update in: Nat Commun. 2023 Mar 29;14(1):1756. doi: 10.1038/s41467-023-37480-2 PMID: 36798426 Free PMC article. Updated. Preprint.
1,641 results