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Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs.
Rathinaswamy MK, Jenkins ML, Duewell BR, Zhang X, Harris NJ, Evans JT, Stariha JTB, Dalwadi U, Fleming KD, Ranga-Prasad H, Yip CK, Williams RL, Hansen SD, Burke JE. Rathinaswamy MK, et al. Among authors: williams rl. Cell Rep. 2023 Mar 28;42(3):112172. doi: 10.1016/j.celrep.2023.112172. Epub 2023 Feb 26. Cell Rep. 2023. PMID: 36842083 Free PMC article.
Form and flexibility in phosphoinositide 3-kinases.
Williams R, Berndt A, Miller S, Hon WC, Zhang X. Williams R, et al. Biochem Soc Trans. 2009 Aug;37(Pt 4):615-26. doi: 10.1042/BST0370615. Biochem Soc Trans. 2009. PMID: 19614567 Review.
Allosteric activation of PI3Kα by oncogenic mutations.
Burke JE, Perisic O, Williams RL. Burke JE, et al. Among authors: williams rl. Oncotarget. 2013 Feb;4(2):180-1. doi: 10.18632/oncotarget.913. Oncotarget. 2013. PMID: 23563630 Free PMC article. No abstract available.
Connecting with an old partner in a new way.
Burke JE, Williams RL. Burke JE, et al. Among authors: williams rl. Cancer Cell. 2013 May 13;23(5):559-61. doi: 10.1016/j.ccr.2013.04.023. Cancer Cell. 2013. PMID: 23680139 Free article.
PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control.
Walser R, Burke JE, Gogvadze E, Bohnacker T, Zhang X, Hess D, Küenzi P, Leitges M, Hirsch E, Williams RL, Laffargue M, Wymann MP. Walser R, et al. Among authors: williams rl. PLoS Biol. 2013;11(6):e1001587. doi: 10.1371/journal.pbio.1001587. Epub 2013 Jun 25. PLoS Biol. 2013. PMID: 23824069 Free PMC article.
899 results