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The structure of pathogenic huntingtin exon 1 defines the bases of its aggregation propensity.
Elena-Real CA, Sagar A, Urbanek A, Popovic M, Morató A, Estaña A, Fournet A, Doucet C, Lund XL, Shi ZD, Costa L, Thureau A, Allemand F, Swenson RE, Milhiet PE, Crehuet R, Barducci A, Cortés J, Sinnaeve D, Sibille N, Bernadó P. Elena-Real CA, et al. Among authors: cortes j. Nat Struct Mol Biol. 2023 Mar;30(3):309-320. doi: 10.1038/s41594-023-00920-0. Epub 2023 Mar 2. Nat Struct Mol Biol. 2023. PMID: 36864173
Flanking Regions Determine the Structure of the Poly-Glutamine in Huntingtin through Mechanisms Common among Glutamine-Rich Human Proteins.
Urbanek A, Popovic M, Morató A, Estaña A, Elena-Real CA, Mier P, Fournet A, Allemand F, Delbecq S, Andrade-Navarro MA, Cortés J, Sibille N, Bernadó P. Urbanek A, et al. Among authors: cortes j. Structure. 2020 Jul 7;28(7):733-746.e5. doi: 10.1016/j.str.2020.04.008. Epub 2020 May 12. Structure. 2020. PMID: 32402249 Free article.
2,836 results