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Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk.
Forteza MJ, Berg M, Edsfeldt A, Sun J, Baumgartner R, Kareinen I, Casagrande FB, Hedin U, Zhang S, Vuckovic I, Dzeja PP, Polyzos KA, Gisterå A, Trauelsen M, Schwartz TW, Dib L, Herrmann J, Monaco C, Matic L, Gonçalves I, Ketelhuth DFJ. Forteza MJ, et al. Among authors: kareinen i. Cardiovasc Res. 2023 Jul 4;119(7):1524-1536. doi: 10.1093/cvr/cvad038. Cardiovasc Res. 2023. PMID: 36866436 Free PMC article.
3-Hydroxyanthralinic acid metabolism controls the hepatic SREBP/lipoprotein axis, inhibits inflammasome activation in macrophages, and decreases atherosclerosis in Ldlr-/- mice.
Berg M, Polyzos KA, Agardh H, Baumgartner R, Forteza MJ, Kareinen I, Gisterå A, Bottcher G, Hurt-Camejo E, Hansson GK, Ketelhuth DFJ. Berg M, et al. Among authors: kareinen i. Cardiovasc Res. 2020 Oct 1;116(12):1948-1957. doi: 10.1093/cvr/cvz258. Cardiovasc Res. 2020. PMID: 31589306 Free PMC article.
Genetic Deficiency of Indoleamine 2,3-dioxygenase Aggravates Vascular but Not Liver Disease in a Nonalcoholic Steatohepatitis and Atherosclerosis Comorbidity Model.
Arora A, Tripodi GL, Kareinen I, Berg M, Forteza MJ, Gisterå A, Griepke S, Casagrande FB, Martins JO, Abdalla DSP, Cole J, Monaco C, Ketelhuth DFJ. Arora A, et al. Among authors: kareinen i. Int J Mol Sci. 2022 May 6;23(9):5203. doi: 10.3390/ijms23095203. Int J Mol Sci. 2022. PMID: 35563591 Free PMC article.
Native and oxidised lipoproteins negatively regulate the serum amyloid A-induced NLRP3 inflammasome activation in human macrophages.
Nurmi K, Niemi K, Kareinen I, Silventoinen K, Lorey MB, Chen Y, Kouri VP, Parantainen J, Juutilainen T, Öörni K, Kovanen PT, Nordström D, Matikainen S, Eklund KK. Nurmi K, et al. Among authors: kareinen i. Clin Transl Immunology. 2021 Aug 3;10(8):e1323. doi: 10.1002/cti2.1323. eCollection 2021. Clin Transl Immunology. 2021. PMID: 34377468 Free PMC article.
Identification of novel genetic risk factors of dilated cardiomyopathy: from canine to human.
Niskanen JE, Ohlsson Å, Ljungvall I, Drögemüller M, Ernst RF, Dooijes D, van Deutekom HWM, van Tintelen JP, Snijders Blok CJB, van Vugt M, van Setten J, Asselbergs FW, Petrič AD, Salonen M, Hundi S, Hörtenhuber M; DoGA consortium; Kere J, Pyle WG, Donner J, Postma AV, Leeb T, Andersson G, Hytönen MK, Häggström J, Wiberg M, Friederich J, Eberhard J, Harakalova M, van Steenbeek FG, Wess G, Lohi H. Niskanen JE, et al. Genome Med. 2023 Sep 18;15(1):73. doi: 10.1186/s13073-023-01221-3. Genome Med. 2023. PMID: 37723491 Free PMC article.
The DoGA consortium expression atlas of promoters and genes in 100 canine tissues.
Hörtenhuber M, Hytönen MK, Mukarram AK, Arumilli M, Araujo CL, Quintero I, Syrjä P, Airas N, Kaukonen M, Kyöstilä K, Niskanen J, Jokinen TS, Mottaghitalab F, Takan I, Salokorpi N, Raman A, Stevens I, Iivanainen A, Yoshihara M, Gusev O, Bannasch D, Sukura A, Schoenebeck JJ; DoGA Consortium; Ezer S, Katayama S, Daub CO, Kere J, Lohi H. Hörtenhuber M, et al. Nat Commun. 2024 Oct 21;15(1):9082. doi: 10.1038/s41467-024-52798-1. Nat Commun. 2024. PMID: 39433728 Free PMC article.
Dog colour patterns explained by modular promoters of ancient canid origin.
Bannasch DL, Kaelin CB, Letko A, Loechel R, Hug P, Jagannathan V, Henkel J, Roosje P, Hytönen MK, Lohi H, Arumilli M; DoGA consortium; Minor KM, Mickelson JR, Drögemüller C, Barsh GS, Leeb T. Bannasch DL, et al. Nat Ecol Evol. 2021 Oct;5(10):1415-1423. doi: 10.1038/s41559-021-01524-x. Epub 2021 Aug 12. Nat Ecol Evol. 2021. PMID: 34385618 Free PMC article.
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