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Proinflammatory phenotype of iPS cell-derived JAK2 V617F megakaryocytes induces fibrosis in 3D in vitro bone marrow niche.
Flosdorf N, Böhnke J, de Toledo MAS, Lutterbach N, Lerma VG, Graßhoff M, Olschok K, Gupta S, Tharmapalan V, Schmitz S, Götz K, Schüler HM, Maurer A, Sontag S, Küstermann C, Seré K, Wagner W, Costa IG, Brümmendorf TH, Koschmieder S, Chatain N, Castilho M, Schneider RK, Zenke M. Flosdorf N, et al. Among authors: zenke m. Stem Cell Reports. 2024 Feb 13;19(2):224-238. doi: 10.1016/j.stemcr.2023.12.011. Epub 2024 Jan 25. Stem Cell Reports. 2024. PMID: 38278152 Free PMC article.
The telomerase inhibitor imetelstat differentially targets JAK2V617F versus CALR mutant myeloproliferative neoplasm cells and inhibits JAK-STAT signaling.
Olschok K, Altenburg B, de Toledo MAS, Maurer A, Abels A, Beier F, Gezer D, Isfort S, Paeschke K, Brümmendorf TH, Zenke M, Chatain N, Koschmieder S. Olschok K, et al. Among authors: zenke m. Front Oncol. 2023 Oct 24;13:1277453. doi: 10.3389/fonc.2023.1277453. eCollection 2023. Front Oncol. 2023. PMID: 37941547 Free PMC article.
YAP1 is essential for self-organized differentiation of pluripotent stem cells.
Zeevaert K, Goetzke R, Elsafi Mabrouk MH, Schmidt M, Maaßen C, Henneke AC, He C, Gillner A, Zenke M, Wagner W. Zeevaert K, et al. Among authors: zenke m. Biomater Adv. 2023 Mar;146:213308. doi: 10.1016/j.bioadv.2023.213308. Epub 2023 Jan 25. Biomater Adv. 2023. PMID: 36774716 Free article.
Capitalizing on paradoxical activation of the mitogen-activated protein kinase pathway for treatment of Imatinib-resistant mast cell leukemia.
Wilhelm T, Toledo MAS, Simons I, Stuth C, Mohta V, Mülfarth R, Nitsche M, Maschke-Neuß K, Schmitz S, Kaiser A, Panse J, Christen D, Arock M, Zenke M, Huber M. Wilhelm T, et al. Among authors: zenke m. Hematol Oncol. 2023 Aug;41(3):520-534. doi: 10.1002/hon.3100. Epub 2022 Nov 30. Hematol Oncol. 2023. PMID: 36383121
Automated CRISPR/Cas9-based genome editing of human pluripotent stem cells using the StemCellFactory.
Nießing B, Breitkreuz Y, Elanzew A, de Toledo MAS, Vajs P, Nolden M, Erkens F, Wanek P, Au Yeung SWC, Haupt S, König N, Peitz M, Schmitt RH, Zenke M, Brüstle O. Nießing B, et al. Among authors: zenke m. Front Bioeng Biotechnol. 2024 Sep 20;12:1459273. doi: 10.3389/fbioe.2024.1459273. eCollection 2024. Front Bioeng Biotechnol. 2024. PMID: 39372431 Free PMC article.
255 results