Gupta A - Search Results

1

Transcription elongation defects link oncogenic splicing factor mutations to targetable alterations in chromatin landscape.

Boddu PC, Gupta A, Roy R, De La Pena Avalos B, Herrero AO, Neuenkirchen N, Zimmer J, Chandhok N, King D, Nannya Y, Ogawa S, Lin H, Simon M, Dray E, Kupfer G, Verma AK, Neugebauer KM, Pillai MM. Boddu PC, et al. Among authors: gupta a. bioRxiv [Preprint]. 2023 Feb 26:2023.02.25.530019. doi: 10.1101/2023.02.25.530019. bioRxiv. 2023. Update in: Mol Cell. 2024 Apr 18;84(8):1475-1495.e18. doi: 10.1016/j.molcel.2024.02.032 PMID: 36891287 Free PMC article. Updated. Preprint.

2

Cyclin-dependent kinase 1 (CDK1) and CDK2 have opposing roles in regulating interactions of splicing factor 3B1 with chromatin.

Murthy T, Bluemn T, Gupta AK, Reimer M Jr, Rao S, Pillai MM, Minella AC. Murthy T, et al. J Biol Chem. 2018 Jun 29;293(26):10220-10234. doi: 10.1074/jbc.RA118.001654. Epub 2018 May 15. J Biol Chem. 2018. PMID: 29764937 Free PMC article.

3

Degenerate minigene library analysis enables identification of altered branch point utilization by mutant splicing factor 3B1 (SF3B1).

Gupta AK, Murthy T, Paul KV, Ramirez O, Fisher JB, Rao S, Rosenberg AB, Seelig G, Minella AC, Pillai MM. Gupta AK, et al. Nucleic Acids Res. 2019 Jan 25;47(2):970-980. doi: 10.1093/nar/gky1161. Nucleic Acids Res. 2019. PMID: 30462273 Free PMC article.

4

Generation of scalable cancer models by combining AAV-intron-trap, CRISPR/Cas9, and inducible Cre-recombinase.

Boddu PC, Gupta AK, Kim JS, Neugebauer KM, Waldman T, Pillai MM. Boddu PC, et al. Commun Biol. 2021 Oct 13;4(1):1184. doi: 10.1038/s42003-021-02690-1. Commun Biol. 2021. PMID: 34645977 Free PMC article.

5

Integrative genome-wide analysis reveals EIF3A as a key downstream regulator of translational repressor protein Musashi 2 (MSI2).

Karmakar S, Ramirez O, Paul KV, Gupta AK, Kumari V, Botti V, de Los Mozos IR, Neuenkirchen N, Ross RJ, Karanicolas J, Neugebauer KM, Pillai MM. Karmakar S, et al. NAR Cancer. 2022 May 2;4(2):zcac015. doi: 10.1093/narcan/zcac015. eCollection 2022 Jun. NAR Cancer. 2022. PMID: 35528200 Free PMC article.

6

Rationally designed inhibitors of the Musashi protein-RNA interaction by hotspot mimicry.

Bai N, Adeshina Y, Bychkov I, Xia Y, Gowthaman R, Miller SA, Gupta AK, Johnson DK, Lan L, Golemis EA, Makhov PB, Xu L, Pillai MM, Boumber Y, Karanicolas J. Bai N, et al. Among authors: gupta ak. bioRxiv [Preprint]. 2023 Jan 10:2023.01.09.523326. doi: 10.1101/2023.01.09.523326. bioRxiv. 2023. PMID: 36711508 Free PMC article. Preprint.

7

The FANCI/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA export.

Olazabal-Herrero A, He B, Kwon Y, Gupta AK, Dutta A, Huang Y, Boddu P, Liang Z, Liang F, Teng Y, Lan L, Chen X, Pei H, Pillai MM, Sung P, Kupfer GM. Olazabal-Herrero A, et al. Among authors: gupta ak. Cell Rep. 2024 Jan 23;43(1):113610. doi: 10.1016/j.celrep.2023.113610. Epub 2024 Jan 1. Cell Rep. 2024. PMID: 38165804 Free PMC article.

8

Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape.

Boddu PC, Gupta AK, Roy R, De La Peña Avalos B, Olazabal-Herrero A, Neuenkirchen N, Zimmer JT, Chandhok NS, King D, Nannya Y, Ogawa S, Lin H, Simon MD, Dray E, Kupfer GM, Verma A, Neugebauer KM, Pillai MM. Boddu PC, et al. Among authors: gupta ak. Mol Cell. 2024 Apr 18;84(8):1475-1495.e18. doi: 10.1016/j.molcel.2024.02.032. Epub 2024 Mar 22. Mol Cell. 2024. PMID: 38521065

9

Cancer-associated SF3B1 mutants recognize otherwise inaccessible cryptic 3' splice sites within RNA secondary structures.

Kesarwani AK, Ramirez O, Gupta AK, Yang X, Murthy T, Minella AC, Pillai MM. Kesarwani AK, et al. Among authors: gupta ak. Oncogene. 2017 Feb 23;36(8):1123-1133. doi: 10.1038/onc.2016.279. Epub 2016 Aug 15. Oncogene. 2017. PMID: 27524419 Free PMC article.

10

Multi-Omics Investigation of Innate Navitoclax Resistance in Triple-Negative Breast Cancer Cells.

Marczyk M, Patwardhan GA, Zhao J, Qu R, Li X, Wali VB, Gupta AK, Pillai MM, Kluger Y, Yan Q, Hatzis C, Pusztai L, Gunasekharan V. Marczyk M, et al. Among authors: gupta ak. Cancers (Basel). 2020 Sep 8;12(9):2551. doi: 10.3390/cancers12092551. Cancers (Basel). 2020. PMID: 32911681 Free PMC article.

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