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Transcription elongation defects link oncogenic splicing factor mutations to targetable alterations in chromatin landscape.
Boddu PC, Gupta A, Roy R, De La Pena Avalos B, Herrero AO, Neuenkirchen N, Zimmer J, Chandhok N, King D, Nannya Y, Ogawa S, Lin H, Simon M, Dray E, Kupfer G, Verma AK, Neugebauer KM, Pillai MM. Boddu PC, et al. Among authors: simon m. bioRxiv [Preprint]. 2023 Feb 26:2023.02.25.530019. doi: 10.1101/2023.02.25.530019. bioRxiv. 2023. Update in: Mol Cell. 2024 Apr 18;84(8):1475-1495.e18. doi: 10.1016/j.molcel.2024.02.032 PMID: 36891287 Free PMC article. Updated. Preprint.
Precision analysis of mutant U2AF1 activity reveals deployment of stress granules in myeloid malignancies.
Biancon G, Joshi P, Zimmer JT, Hunck T, Gao Y, Lessard MD, Courchaine E, Barentine AES, Machyna M, Botti V, Qin A, Gbyli R, Patel A, Song Y, Kiefer L, Viero G, Neuenkirchen N, Lin H, Bewersdorf J, Simon MD, Neugebauer KM, Tebaldi T, Halene S. Biancon G, et al. Among authors: simon md. Mol Cell. 2022 Mar 17;82(6):1107-1122.e7. doi: 10.1016/j.molcel.2022.02.025. Mol Cell. 2022. PMID: 35303483 Free PMC article.
Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape.
Boddu PC, Gupta AK, Roy R, De La Peña Avalos B, Olazabal-Herrero A, Neuenkirchen N, Zimmer JT, Chandhok NS, King D, Nannya Y, Ogawa S, Lin H, Simon MD, Dray E, Kupfer GM, Verma A, Neugebauer KM, Pillai MM. Boddu PC, et al. Among authors: simon md. Mol Cell. 2024 Apr 18;84(8):1475-1495.e18. doi: 10.1016/j.molcel.2024.02.032. Epub 2024 Mar 22. Mol Cell. 2024. PMID: 38521065
Rapid folding of nascent RNA regulates eukaryotic RNA biogenesis.
Schärfen L, Vock IW, Simon MD, Neugebauer KM. Schärfen L, et al. Among authors: simon md. bioRxiv [Preprint]. 2024 Nov 26:2024.11.26.625435. doi: 10.1101/2024.11.26.625435. bioRxiv. 2024. PMID: 39651172 Free PMC article. Preprint.
E-box independent chromatin recruitment turns MYOD into a transcriptional repressor.
Nicoletti C, Massenet J, Pintado-Urbanc AP, Connor LJ, Nicolau M, Sundar S, Xu M, Schmitt A, Zhang W, Fang Z, Chan TCI, Tapscott SJ, Cheung TH, Simon MD, Caputo L, Puri PL. Nicoletti C, et al. Among authors: simon md. bioRxiv [Preprint]. 2024 Dec 5:2024.12.05.627024. doi: 10.1101/2024.12.05.627024. bioRxiv. 2024. PMID: 39677796 Free PMC article. Preprint.
Nuclear speckles regulate functional programs in cancer.
Alexander KA, Yu R, Skuli N, Coffey NJ, Nguyen S, Faunce CL, Huang H, Dardani IP, Good AL, Lim J, Li CY, Biddle N, Joyce EF, Raj A, Lee D, Keith B, Simon MC, Berger SL. Alexander KA, et al. Among authors: simon mc. Nat Cell Biol. 2025 Jan 2. doi: 10.1038/s41556-024-01570-0. Online ahead of print. Nat Cell Biol. 2025. PMID: 39747580
6,526 results