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182,467 results

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Page 1
De novo design of small beta barrel proteins.
Kim DE, Jensen DR, Feldman D, Tischer D, Saleem A, Chow CM, Li X, Carter L, Milles L, Nguyen H, Kang A, Bera AK, Peterson FC, Volkman BF, Ovchinnikov S, Baker D. Kim DE, et al. Among authors: li x. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2207974120. doi: 10.1073/pnas.2207974120. Epub 2023 Mar 10. Proc Natl Acad Sci U S A. 2023. PMID: 36897987 Free PMC article.
Computationally designed peptide macrocycle inhibitors of New Delhi metallo-β-lactamase 1.
Mulligan VK, Workman S, Sun T, Rettie S, Li X, Worrall LJ, Craven TW, King DT, Hosseinzadeh P, Watkins AM, Renfrew PD, Guffy S, Labonte JW, Moretti R, Bonneau R, Strynadka NCJ, Baker D. Mulligan VK, et al. Among authors: li x. Proc Natl Acad Sci U S A. 2021 Mar 23;118(12):e2012800118. doi: 10.1073/pnas.2012800118. Proc Natl Acad Sci U S A. 2021. PMID: 33723038 Free PMC article.
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites.
Hosseinzadeh P, Watson PR, Craven TW, Li X, Rettie S, Pardo-Avila F, Bera AK, Mulligan VK, Lu P, Ford AS, Weitzner BD, Stewart LJ, Moyer AP, Di Piazza M, Whalen JG, Greisen PJ, Christianson DW, Baker D. Hosseinzadeh P, et al. Among authors: li x. Nat Commun. 2021 Jun 7;12(1):3384. doi: 10.1038/s41467-021-23609-8. Nat Commun. 2021. PMID: 34099674 Free PMC article.
Accurate de novo design of membrane-traversing macrocycles.
Bhardwaj G, O'Connor J, Rettie S, Huang YH, Ramelot TA, Mulligan VK, Alpkilic GG, Palmer J, Bera AK, Bick MJ, Di Piazza M, Li X, Hosseinzadeh P, Craven TW, Tejero R, Lauko A, Choi R, Glynn C, Dong L, Griffin R, van Voorhis WC, Rodriguez J, Stewart L, Montelione GT, Craik D, Baker D. Bhardwaj G, et al. Among authors: li x. Cell. 2022 Sep 15;185(19):3520-3532.e26. doi: 10.1016/j.cell.2022.07.019. Epub 2022 Aug 29. Cell. 2022. PMID: 36041435 Free PMC article.
Design of stimulus-responsive two-state hinge proteins.
Praetorius F, Leung PJY, Tessmer MH, Broerman A, Demakis C, Dishman AF, Pillai A, Idris A, Juergens D, Dauparas J, Li X, Levine PM, Lamb M, Ballard RK, Gerben SR, Nguyen H, Kang A, Sankaran B, Bera AK, Volkman BF, Nivala J, Stoll S, Baker D. Praetorius F, et al. Among authors: li x. Science. 2023 Aug 18;381(6659):754-760. doi: 10.1126/science.adg7731. Epub 2023 Aug 17. Science. 2023. PMID: 37590357 Free PMC article.
De novo design of buttressed loops for sculpting protein functions.
Jiang H, Jude KM, Wu K, Fallas J, Ueda G, Brunette TJ, Hicks D, Pyles H, Yang A, Carter L, Lamb M, Li X, Levine PM, Stewart L, Garcia KC, Baker D. Jiang H, et al. Among authors: li x. bioRxiv [Preprint]. 2023 Aug 23:2023.08.22.554384. doi: 10.1101/2023.08.22.554384. bioRxiv. 2023. Update in: Nat Chem Biol. 2024 Aug;20(8):974-980. doi: 10.1038/s41589-024-01632-2 PMID: 37662224 Free PMC article. Updated. Preprint.
Precisely patterned nanofibres made from extendable protein multiplexes.
Bethel NP, Borst AJ, Parmeggiani F, Bick MJ, Brunette TJ, Nguyen H, Kang A, Bera AK, Carter L, Miranda MC, Kibler RD, Lamb M, Li X, Sankaran B, Baker D. Bethel NP, et al. Among authors: li x. Nat Chem. 2023 Dec;15(12):1664-1671. doi: 10.1038/s41557-023-01314-x. Epub 2023 Sep 4. Nat Chem. 2023. PMID: 37667012 Free PMC article.
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