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Page 1
Molecular mechanism of biased signaling at the kappa opioid receptor.
El Daibani A, Paggi JM, Kim K, Laloudakis YD, Popov P, Bernhard SM, Krumm BE, Olsen RHJ, Diberto J, Carroll FI, Katritch V, Wünsch B, Dror RO, Che T. El Daibani A, et al. Among authors: krumm be. Nat Commun. 2023 Mar 11;14(1):1338. doi: 10.1038/s41467-023-37041-7. Nat Commun. 2023. PMID: 36906681 Free PMC article.
Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.
Che T, Majumdar S, Zaidi SA, Ondachi P, McCorvy JD, Wang S, Mosier PD, Uprety R, Vardy E, Krumm BE, Han GW, Lee MY, Pardon E, Steyaert J, Huang XP, Strachan RT, Tribo AR, Pasternak GW, Carroll FI, Stevens RC, Cherezov V, Katritch V, Wacker D, Roth BL. Che T, et al. Among authors: krumm be. Cell. 2018 Jan 11;172(1-2):55-67.e15. doi: 10.1016/j.cell.2017.12.011. Epub 2018 Jan 4. Cell. 2018. PMID: 29307491 Free PMC article.
Nanobody-enabled monitoring of kappa opioid receptor states.
Che T, English J, Krumm BE, Kim K, Pardon E, Olsen RHJ, Wang S, Zhang S, Diberto JF, Sciaky N, Carroll FI, Steyaert J, Wacker D, Roth BL. Che T, et al. Among authors: krumm be. Nat Commun. 2020 Mar 2;11(1):1145. doi: 10.1038/s41467-020-14889-7. Nat Commun. 2020. PMID: 32123179 Free PMC article.
TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome.
Olsen RHJ, DiBerto JF, English JG, Glaudin AM, Krumm BE, Slocum ST, Che T, Gavin AC, McCorvy JD, Roth BL, Strachan RT. Olsen RHJ, et al. Among authors: krumm be. Nat Chem Biol. 2020 Aug;16(8):841-849. doi: 10.1038/s41589-020-0535-8. Epub 2020 May 4. Nat Chem Biol. 2020. PMID: 32367019 Free PMC article.
Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor.
Kim K, Che T, Panova O, DiBerto JF, Lyu J, Krumm BE, Wacker D, Robertson MJ, Seven AB, Nichols DE, Shoichet BK, Skiniotis G, Roth BL. Kim K, et al. Among authors: krumm be. Cell. 2020 Sep 17;182(6):1574-1588.e19. doi: 10.1016/j.cell.2020.08.024. Cell. 2020. PMID: 32946782 Free PMC article.
Structure, function and pharmacology of human itch GPCRs.
Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL. Cao C, et al. Among authors: krumm be. Nature. 2021 Dec;600(7887):170-175. doi: 10.1038/s41586-021-04126-6. Epub 2021 Nov 17. Nature. 2021. PMID: 34789874 Free PMC article.
Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD.
Cao C, Barros-Álvarez X, Zhang S, Kim K, Dämgen MA, Panova O, Suomivuori CM, Fay JF, Zhong X, Krumm BE, Gumpper RH, Seven AB, Robertson MJ, Krogan NJ, Hüttenhain R, Nichols DE, Dror RO, Skiniotis G, Roth BL. Cao C, et al. Among authors: krumm be. Neuron. 2022 Oct 5;110(19):3154-3167.e7. doi: 10.1016/j.neuron.2022.08.006. Epub 2022 Sep 9. Neuron. 2022. PMID: 36087581 Free PMC article.
Ligand and G-protein selectivity in the κ-opioid receptor.
Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T. Han J, et al. Among authors: krumm be. Nature. 2023 May;617(7960):417-425. doi: 10.1038/s41586-023-06030-7. Epub 2023 May 3. Nature. 2023. PMID: 37138078 Free PMC article.
32 results