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The hereditary N363K POLE exonuclease mutant extends PPAP tumor spectrum to glioblastomas by causing DNA damage and aneuploidy in addition to increased mismatch mutagenicity.
Labrousse G, Vande Perre P, Parra G, Jaffrelot M, Leroy L, Chibon F, Escudie F, Selves J, Hoffmann JS, Guimbaud R, Lutzmann M. Labrousse G, et al. Among authors: leroy l. NAR Cancer. 2023 Mar 11;5(2):zcad011. doi: 10.1093/narcan/zcad011. eCollection 2023 Jun. NAR Cancer. 2023. PMID: 36915289 Free PMC article.
Association of the Lung Immune Prognostic Index With Immune Checkpoint Inhibitor Outcomes in Patients With Advanced Non-Small Cell Lung Cancer.
Mezquita L, Auclin E, Ferrara R, Charrier M, Remon J, Planchard D, Ponce S, Ares LP, Leroy L, Audigier-Valette C, Felip E, Zerón-Medina J, Garrido P, Brosseau S, Zalcman G, Mazieres J, Caramela C, Lahmar J, Adam J, Chaput N, Soria JC, Besse B. Mezquita L, et al. Among authors: leroy l. JAMA Oncol. 2018 Mar 1;4(3):351-357. doi: 10.1001/jamaoncol.2017.4771. JAMA Oncol. 2018. PMID: 29327044 Free PMC article.
ATRX Alteration Contributes to Tumor Growth and Immune Escape in Pleomorphic Sarcomas.
Darmusey L, Pérot G, Thébault N, Le Guellec S, Desplat N, Gaston L, Delespaul L, Lesluyes T, Darbo E, Gomez-Brouchet A, Richard E, Baud J, Leroy L, Coindre JM, Blay JY, Chibon F. Darmusey L, et al. Among authors: leroy l. Cancers (Basel). 2021 Apr 29;13(9):2151. doi: 10.3390/cancers13092151. Cancers (Basel). 2021. PMID: 33946962 Free PMC article.
Medium levels of transcription and replication related chromosomal instability are associated with poor clinical outcome.
Benhaddou A, Gaston L, Pérot G, Desplat N, Leroy L, Le Guellec S, Ben Haddou M, Rochaix P, Valentin T, Ferron G, Chevreau C, Bui B, Stoeckle E, Le Cesne A, Piperno-Neumann S, Collin F, Firmin N, De Pinieux G, Coindre JM, Blay JY, Chibon F. Benhaddou A, et al. Among authors: leroy l. Sci Rep. 2021 Dec 6;11(1):23429. doi: 10.1038/s41598-021-02787-x. Sci Rep. 2021. PMID: 34873180 Free PMC article.
Distinct Cellular Origins and Differentiation Process Account for Distinct Oncogenic and Clinical Behaviors of Leiomyosarcomas.
Darbo E, Pérot G, Darmusey L, Le Guellec S, Leroy L, Gaston L, Desplat N, Thébault N, Merle C, Rochaix P, Valentin T, Ferron G, Chevreau C, Bui B, Stoeckle E, Ranchere-Vince D, Méeus P, Terrier P, Piperno-Neumann S, Collin F, De Pinieux G, Duffaud F, Coindre JM, Blay JY, Chibon F. Darbo E, et al. Among authors: leroy l. Cancers (Basel). 2023 Jan 15;15(2):534. doi: 10.3390/cancers15020534. Cancers (Basel). 2023. PMID: 36672483 Free PMC article.
Antitumor Effects of PRMT5 Inhibition in Sarcomas.
Verbeke S, Bourdon A, Guegan JP, Leroy L, Chaire V, Richard E, Bessede A, Italiano A. Verbeke S, et al. Among authors: leroy l. Cancer Res Commun. 2023 Nov 2;3(11):2211-2220. doi: 10.1158/2767-9764.CRC-23-0239. Cancer Res Commun. 2023. PMID: 37861293 Free PMC article.
Analysis of PD1, LAG3, TIGIT, and TIM3 expression in human lung adenocarcinoma reveals a 25-gene signature predicting immunotherapy response.
Guégan JP, Peyraud F, Dadone-Montaudie B, Teyssonneau D, Palmieri LJ, Clot E, Cousin S, Roubaud G, Cabart M, Leroy L, Lebreton C, Rey C, Lara O, Odin O, Brunet M, Vanhersecke L, Gruyters EO, Achour I, Belcaid L, Le Moulec S, Grellety T, Bessede A, Italiano A. Guégan JP, et al. Among authors: leroy l. Cell Rep Med. 2024 Dec 17;5(12):101831. doi: 10.1016/j.xcrm.2024.101831. Epub 2024 Nov 25. Cell Rep Med. 2024. PMID: 39591972 Free PMC article.
131 results