Graña X - Search Results

1

FAM122A ensures cell cycle interphase progression and checkpoint control as a SLiM-dependent substrate-competitive inhibitor to the B55⍺/PP2A phosphatase.

Wasserman JS, Faezov B, Patel KR, Kurimchak AN, Palacio SM, Fowle H, McEwan BC, Xu Q, Zhao Z, Cressey L, Johnson N, Duncan JS, Kettenbach AN, Dunbrack RL, Graña X. Wasserman JS, et al. Among authors: grana x. bioRxiv [Preprint]. 2023 Mar 17:2023.03.06.531310. doi: 10.1101/2023.03.06.531310. bioRxiv. 2023. PMID: 36945596 Free PMC article. Preprint.

2

Cyclin E and SV40 small T antigen cooperate to bypass quiescence and contribute to transformation by activating CDK2 in human fibroblasts.

Sotillo E, Garriga J, Kurimchak A, Graña X. Sotillo E, et al. Among authors: grana x. J Biol Chem. 2008 Apr 25;283(17):11280-92. doi: 10.1074/jbc.M709055200. Epub 2008 Feb 14. J Biol Chem. 2008. PMID: 18276582 Free PMC article.

3

B55alpha PP2A holoenzymes modulate the phosphorylation status of the retinoblastoma-related protein p107 and its activation.

Jayadeva G, Kurimchak A, Garriga J, Sotillo E, Davis AJ, Haines DS, Mumby M, Graña X. Jayadeva G, et al. Among authors: grana x. J Biol Chem. 2010 Sep 24;285(39):29863-73. doi: 10.1074/jbc.M110.162354. Epub 2010 Jul 27. J Biol Chem. 2010. PMID: 20663872 Free PMC article.

4

PP2A holoenzymes negatively and positively regulate cell cycle progression by dephosphorylating pocket proteins and multiple CDK substrates.

Kurimchak A, Graña X. Kurimchak A, et al. Among authors: grana x. Gene. 2012 May 10;499(1):1-7. doi: 10.1016/j.gene.2012.02.015. Epub 2012 Feb 22. Gene. 2012. PMID: 22387205 Free PMC article. Review.

5

PP2A Counterbalances Phosphorylation of pRB and Mitotic Proteins by Multiple CDKs: Potential Implications for PP2A Disruption in Cancer.

Kurimchak A, Graña X. Kurimchak A, et al. Among authors: grana x. Genes Cancer. 2012 Nov;3(11-12):739-48. doi: 10.1177/1947601912473479. Genes Cancer. 2012. PMID: 23634261 Free PMC article.

6

Activation of p107 by fibroblast growth factor, which is essential for chondrocyte cell cycle exit, is mediated by the protein phosphatase 2A/B55α holoenzyme.

Kurimchak A, Haines DS, Garriga J, Wu S, De Luca F, Sweredoski MJ, Deshaies RJ, Hess S, Graña X. Kurimchak A, et al. Among authors: grana x. Mol Cell Biol. 2013 Aug;33(16):3330-42. doi: 10.1128/MCB.00082-13. Epub 2013 Jun 17. Mol Cell Biol. 2013. PMID: 23775125 Free PMC article.

7

PP2A: more than a reset switch to activate pRB proteins during the cell cycle and in response to signaling cues.

Kurimchak A, Graña X. Kurimchak A, et al. Among authors: grana x. Cell Cycle. 2015;14(1):18-30. doi: 10.4161/15384101.2014.985069. Cell Cycle. 2015. PMID: 25483052 Free PMC article. Review.

8

PP2A holoenzymes, substrate specificity driving cellular functions and deregulation in cancer.

Fowle H, Zhao Z, Graña X. Fowle H, et al. Among authors: grana x. Adv Cancer Res. 2019;144:55-93. doi: 10.1016/bs.acr.2019.03.009. Epub 2019 Apr 12. Adv Cancer Res. 2019. PMID: 31349904 Free PMC article. Review.

9

PPP2R2A prostate cancer haploinsufficiency is associated with worse prognosis and a high vulnerability to B55α/PP2A reconstitution that triggers centrosome destabilization.

Zhao Z, Kurimchak A, Nikonova AS, Feiser F, Wasserman JS, Fowle H, Varughese T, Connors M, Johnson K, Makhov P, Lindskog C, Kolenko VM, Golemis EA, Duncan JS, Graña X. Zhao Z, et al. Among authors: grana x. Oncogenesis. 2019 Dec 10;8(12):72. doi: 10.1038/s41389-019-0180-9. Oncogenesis. 2019. PMID: 31822657 Free PMC article.

10

PP2A/B55α substrate recruitment as defined by the retinoblastoma-related protein p107.

Fowle H, Zhao Z, Xu Q, Wasserman JS, Wang X, Adeyemi M, Feiser F, Kurimchak AN, Atar D, McEwan BC, Kettenbach AN, Page R, Peti W, Dunbrack RL, Graña X. Fowle H, et al. Among authors: grana x. Elife. 2021 Oct 18;10:e63181. doi: 10.7554/eLife.63181. Elife. 2021. PMID: 34661528 Free PMC article.

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