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Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination-Deficient Leukemia Cells.
Sullivan-Reed K, Toma MM, Drzewiecka M, Nieborowska-Skorska M, Nejati R, Karami A, Wasik MA, Sliwinski T, Skorski T. Sullivan-Reed K, et al. Among authors: sliwinski t. Mol Cancer Res. 2023 Oct 2;21(10):1017-1022. doi: 10.1158/1541-7786.MCR-22-1035. Mol Cancer Res. 2023. PMID: 37358557 Free PMC article.
Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile.
Cramer-Morales K, Nieborowska-Skorska M, Scheibner K, Padget M, Irvine DA, Sliwinski T, Haas K, Lee J, Geng H, Roy D, Slupianek A, Rassool FV, Wasik MA, Childers W, Copland M, Müschen M, Civin CI, Skorski T. Cramer-Morales K, et al. Among authors: sliwinski t. Blood. 2013 Aug 15;122(7):1293-304. doi: 10.1182/blood-2013-05-501072. Epub 2013 Jul 8. Blood. 2013. PMID: 23836560 Free PMC article.
DNA polymerase θ protects leukemia cells from metabolically induced DNA damage.
Vekariya U, Toma M, Nieborowska-Skorska M, Le BV, Caron MC, Kukuyan AM, Sullivan-Reed K, Podszywalow-Bartnicka P, Chitrala KN, Atkins J, Drzewiecka M, Feng W, Chan J, Chatla S, Golovine K, Jelinek J, Sliwinski T, Ghosh J, Matlawska-Wasowska K, Chandramouly G, Nejati R, Wasik M, Sykes SM, Piwocka K, Hadzijusufovic E, Valent P, Pomerantz RT, Morton G, Childers W, Zhao H, Paietta EM, Levine RL, Tallman MS, Fernandez HF, Litzow MR, Gupta GP, Masson JY, Skorski T. Vekariya U, et al. Among authors: sliwinski t. Blood. 2023 May 11;141(19):2372-2389. doi: 10.1182/blood.2022018428. Blood. 2023. PMID: 36580665 Free PMC article.
144 results