Chang CCY - Search Results

1

Acute ACAT1/SOAT1 Blockade Increases MAM Cholesterol and Strengthens ER-Mitochondria Connectivity.

Harned TC, Stan RV, Cao Z, Chakrabarti R, Higgs HN, Chang CCY, Chang TY. Harned TC, et al. Among authors: chang ccy. Int J Mol Sci. 2023 Mar 14;24(6):5525. doi: 10.3390/ijms24065525. Int J Mol Sci. 2023. PMID: 36982602 Free PMC article.

2

Plasma membrane cholesterol: a possible barrier to intracellular oxygen in normal and mutant CHO cells defective in cholesterol metabolism.

Khan N, Shen J, Chang TY, Chang CC, Fung PC, Grinberg O, Demidenko E, Swartz H. Khan N, et al. Biochemistry. 2003 Jan 14;42(1):23-9. doi: 10.1021/bi026039t. Biochemistry. 2003. PMID: 12515536

3

Partial blockage of sterol biosynthesis with a squalene synthase inhibitor in early postnatal Niemann-Pick type C npcnih null mice brains reduces neuronal cholesterol accumulation, abrogates astrogliosis, but may inhibit myelin maturation.

Reid PC, Lin S, Vanier MT, Ohno-Iwashita Y, Harwood HJ Jr, Hickey WF, Chang CC, Chang TY. Reid PC, et al. J Neurosci Methods. 2008 Feb 15;168(1):15-25. doi: 10.1016/j.jneumeth.2007.09.002. Epub 2007 Sep 12. J Neurosci Methods. 2008. PMID: 17949821 Free PMC article.

4

Transport of LDL-derived cholesterol from the NPC1 compartment to the ER involves the trans-Golgi network and the SNARE protein complex.

Urano Y, Watanabe H, Murphy SR, Shibuya Y, Geng Y, Peden AA, Chang CC, Chang TY. Urano Y, et al. Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16513-8. doi: 10.1073/pnas.0807450105. Epub 2008 Oct 22. Proc Natl Acad Sci U S A. 2008. PMID: 18946045 Free PMC article.

5

Neuronal cholesterol esterification by ACAT1 in Alzheimer's disease.

Chang TY, Chang CC, Bryleva E, Rogers MA, Murphy SR. Chang TY, et al. IUBMB Life. 2010 Apr;62(4):261-7. doi: 10.1002/iub.305. IUBMB Life. 2010. PMID: 20101629 Free article. Review.

6

ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.

Bryleva EY, Rogers MA, Chang CC, Buen F, Harris BT, Rousselet E, Seidah NG, Oddo S, LaFerla FM, Spencer TA, Hickey WF, Chang TY. Bryleva EY, et al. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3081-6. doi: 10.1073/pnas.0913828107. Epub 2010 Jan 26. Proc Natl Acad Sci U S A. 2010. PMID: 20133765 Free PMC article.

7

Purification of recombinant acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) from H293 cells and binding studies between the enzyme and substrates using difference intrinsic fluorescence spectroscopy.

Chang CC, Miyazaki A, Dong R, Kheirollah A, Yu C, Geng Y, Higgs HN, Chang TY. Chang CC, et al. Biochemistry. 2010 Nov 23;49(46):9957-63. doi: 10.1021/bi1013936. Epub 2010 Oct 29. Biochemistry. 2010. PMID: 20964445 Free PMC article.

8

Acat1 knockdown gene therapy decreases amyloid-β in a mouse model of Alzheimer's disease.

Murphy SR, Chang CC, Dogbevia G, Bryleva EY, Bowen Z, Hasan MT, Chang TY. Murphy SR, et al. Mol Ther. 2013 Aug;21(8):1497-506. doi: 10.1038/mt.2013.118. Epub 2013 Jun 18. Mol Ther. 2013. PMID: 23774792 Free PMC article.

9

ACAT1/SOAT1 as a therapeutic target for Alzheimer's disease.

Shibuya Y, Chang CC, Chang TY. Shibuya Y, et al. Future Med Chem. 2015;7(18):2451-67. doi: 10.4155/fmc.15.161. Epub 2015 Dec 15. Future Med Chem. 2015. PMID: 26669800 Free PMC article. Review.

10

Myeloid Acat1/Soat1 KO attenuates pro-inflammatory responses in macrophages and protects against atherosclerosis in a model of advanced lesions.

Melton EM, Li H, Benson J, Sohn P, Huang LH, Song BL, Li BL, Chang CCY, Chang TY. Melton EM, et al. Among authors: chang ccy, chang ty. J Biol Chem. 2019 Oct 25;294(43):15836-15849. doi: 10.1074/jbc.RA119.010564. Epub 2019 Sep 8. J Biol Chem. 2019. PMID: 31495784 Free PMC article.

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