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Engineered Escherichia coli for the in situ secretion of therapeutic nanobodies in the gut.
Lynch JP, González-Prieto C, Reeves AZ, Bae S, Powale U, Godbole NP, Tremblay JM, Schmidt FI, Ploegh HL, Kansra V, Glickman JN, Leong JM, Shoemaker CB, Garrett WS, Lesser CF. Lynch JP, et al. Among authors: leong jm. Cell Host Microbe. 2023 Apr 12;31(4):634-649.e8. doi: 10.1016/j.chom.2023.03.007. Epub 2023 Mar 31. Cell Host Microbe. 2023. PMID: 37003258 Free PMC article.
Whole genome sequencing of Borrelia burgdorferi isolates reveals linked clusters of plasmid-borne accessory genome elements associated with virulence.
Lemieux JE, Huang W, Hill N, Cerar T, Freimark L, Hernandez S, Luban M, Maraspin V, Bogovic P, Ogrinc K, Ruzic-Sabljic E, Lapierre P, Lasek-Nesselquist E, Singh N, Iyer R, Liveris D, Reed KD, Leong JM, Branda JA, Steere AC, Wormser GP, Strle F, Sabeti PC, Schwartz I, Strle K. Lemieux JE, et al. Among authors: leong jm. bioRxiv [Preprint]. 2023 Feb 27:2023.02.26.530159. doi: 10.1101/2023.02.26.530159. bioRxiv. 2023. Update in: PLoS Pathog. 2023 Aug 31;19(8):e1011243. doi: 10.1371/journal.ppat.1011243. PMID: 36909473 Free PMC article. Updated. Preprint.
In situ deposition of nanobodies by an engineered commensal microbe promotes survival in a mouse model of enterohemorrhagic E. coli.
Srivastava R, González-Prieto C, Lynch JP, Muscolo M, Lin CY, Brown MA, Lemos L, Shrestha A, Osburne MS, Leong JM, Lesser CF. Srivastava R, et al. Among authors: leong jm. bioRxiv [Preprint]. 2024 Jul 30:2024.07.30.605899. doi: 10.1101/2024.07.30.605899. bioRxiv. 2024. Update in: PNAS Nexus. 2024 Sep 02;3(9):pgae374. doi: 10.1093/pnasnexus/pgae374. PMID: 39131305 Free PMC article. Updated. Preprint.
Blocking HXA3-mediated neutrophil elastase release during S. pneumoniae lung infection limits pulmonary epithelial barrier disruption and bacteremia.
Xu S, Tan S, Romanos P, Reedy JL, Zhang Y, Mansour MK, Vyas JM, Mecsas J, Mou H, Leong JM. Xu S, et al. Among authors: leong jm. bioRxiv [Preprint]. 2024 Jun 25:2024.06.25.600637. doi: 10.1101/2024.06.25.600637. bioRxiv. 2024. Update in: mBio. 2024 Sep 11;15(9):e0185624. doi: 10.1128/mbio.01856-24. PMID: 38979170 Free PMC article. Updated. Preprint.
Corrigendum: Safe and effective delivery of supplemental iron to healthy adults: a two-phase, randomized, double-blind trial - the safe iron study.
Lewis ED, Ortega EF, Dao MC, Barger K, Mason JB, Leong JM, Osburne MS, Magoun L, Nepveux FJ, Chishti AH, Schwake C, Quynh A, Gilhooly CH, Petty G, Guo W, Matuszek G, Pereira D, Reddy M, Wang J, Wu D, Meydani SN, Combs GF Jr. Lewis ED, et al. Among authors: leong jm. Front Nutr. 2024 Feb 27;11:1376599. doi: 10.3389/fnut.2024.1376599. eCollection 2024. Front Nutr. 2024. PMID: 38476600 Free PMC article.
150 results