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Bortezomib interferes with C-KIT processing and transforms the t(8;21)-generated fusion proteins into tumor-suppressing fragments in leukemia cells.
Fang HT, Zhang B, Pan XF, Gao L, Zhen T, Zhao HX, Ma L, Xie J, Liu Z, Yu XJ, Cheng X, Feng TT, Zhang FX, Yang Y, Hu ZG, Sheng GQ, Chen YL, Chen SJ, Chen Z, Zhou GB. Fang HT, et al. Among authors: yu xj. Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2521-6. doi: 10.1073/pnas.1121341109. Epub 2012 Jan 27. Proc Natl Acad Sci U S A. 2012. PMID: 22308476 Free PMC article.
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