Kavthe RD - Search Results

1

Direct formation of amide/peptide bonds from carboxylic acids: no traditional coupling reagents, 1-pot, and green.

Freiberg KM, Kavthe RD, Thomas RM, Fialho DM, Dee P, Scurria M, Lipshutz BH. Freiberg KM, et al. Among authors: kavthe rd. Chem Sci. 2023 Feb 28;14(13):3462-3469. doi: 10.1039/d3sc00198a. eCollection 2023 Mar 29. Chem Sci. 2023. PMID: 37006678 Free PMC article.

2

A sustainable, efficient, and potentially cost-effective approach to the antimalarial drug candidate MMV688533.

Kavthe RD, Iyer KS, Caravez JC, Lipshutz BH. Kavthe RD, et al. Chem Sci. 2023 May 26;14(23):6399-6407. doi: 10.1039/d3sc01699d. eCollection 2023 Jun 14. Chem Sci. 2023. PMID: 37325157 Free PMC article.

3

Nanoparticles as Heterogeneous Catalysts for ppm Pd-Catalyzed Aminations in Water.

Iyer K, Kavthe R, Hu Y, Lipshutz BH. Iyer K, et al. ACS Sustain Chem Eng. 2024 Jan 22;12(5):1997-2008. doi: 10.1021/acssuschemeng.3c06527. eCollection 2024 Feb 5. ACS Sustain Chem Eng. 2024. PMID: 38333203 Free PMC article.

4

Rapid Aminations of Functionalized Aryl Fluorosulfates in Water.

Iyer KS, Dismuke Rodriguez KB, Lammert RM, Yirak JR, Saunders JM, Kavthe RD, Aue DH, Lipshutz BH. Iyer KS, et al. Among authors: kavthe rd. Angew Chem Int Ed Engl. 2024 Oct 21;63(43):e202411295. doi: 10.1002/anie.202411295. Epub 2024 Sep 6. Angew Chem Int Ed Engl. 2024. PMID: 39034288

5

Ligated Pd-Catalyzed Aminations of Aryl/Heteroaryl Halides with Aliphatic Amines under Sustainable Aqueous Micellar Conditions.

Iyer KS, Kavthe RD, Lammert RM, Yirak JR, Lipshutz BH. Iyer KS, et al. Among authors: kavthe rd. JACS Au. 2024 Feb 12;4(2):680-689. doi: 10.1021/jacsau.3c00742. eCollection 2024 Feb 26. JACS Au. 2024. PMID: 38425930 Free PMC article.

6

A Streamlined, Green, and Sustainable Synthesis of the Anticancer Agent Erdafitinib.

Singhania V, Nelson CB, Reamey M, Morin E, Kavthe RD, Lipshutz BH. Singhania V, et al. Among authors: kavthe rd. Org Lett. 2023 Jun 16;25(23):4308-4312. doi: 10.1021/acs.orglett.3c01380. Epub 2023 Jun 6. Org Lett. 2023. PMID: 37278485

7

An Efficient and Sustainable Synthesis of the Antimalarial Drug Tafenoquine.

Kavthe RD, Kincaid JRA, Lipshutz BH. Kavthe RD, et al. ACS Sustain Chem Eng. 2022 Dec 19;10(50):16896-16902. doi: 10.1021/acssuschemeng.2c05628. Epub 2022 Dec 7. ACS Sustain Chem Eng. 2022. PMID: 36569493 Free PMC article.

8

A 1-Pot Synthesis of the SARS-CoV-2 M^pro Inhibitor Nirmatrelvir, the Key Ingredient in Paxlovid.

Caravez JC, Iyer KS, Kavthe RD, Kincaid JRA, Lipshutz BH. Caravez JC, et al. Among authors: kavthe rd. Org Lett. 2022 Dec 16;24(49):9049-9053. doi: 10.1021/acs.orglett.2c03683. Epub 2022 Dec 7. Org Lett. 2022. PMID: 36475781 Free PMC article.

9

A sustainable synthesis of the SARS-CoV-2 M^pro inhibitor nirmatrelvir, the active ingredient in Paxlovid.

Kincaid JRA, Caravez JC, Iyer KS, Kavthe RD, Fleck N, Aue DH, Lipshutz BH. Kincaid JRA, et al. Among authors: kavthe rd. Commun Chem. 2022;5(1):156. doi: 10.1038/s42004-022-00758-5. Epub 2022 Nov 21. Commun Chem. 2022. PMID: 36465589 Free PMC article.

10

Environmentally Responsible and Cost-Effective Synthesis of the Antimalarial Drug Pyronaridine.

Kincaid JRA, Kavthe RD, Caravez JC, Takale BS, Thakore RR, Lipshutz BH. Kincaid JRA, et al. Among authors: kavthe rd. Org Lett. 2022 May 13;24(18):3342-3346. doi: 10.1021/acs.orglett.2c00944. Epub 2022 May 3. Org Lett. 2022. PMID: 35504038 Free PMC article.

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