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Leishmania infantum NTPDase1 and NTPDase2 play an important role in infection and nitric oxide production in macrophages.
da Silva W, Ribeiro IC, Agripino JM, da Silva VHF, de Souza LÂ, Oliveira TA, Bressan GC, Vasconcellos RS, Dumas C, Pelletier J, Sévigny J, Papadopoulou B, Fietto JLR. da Silva W, et al. Among authors: sevigny j. Acta Trop. 2023 Jan;237:106732. doi: 10.1016/j.actatropica.2022.106732. Epub 2022 Oct 27. Acta Trop. 2023. PMID: 36309108 Free article.
Design and synthesis of new adamantyl derivatives as promising antiproliferative agents.
Shahin AI, Zaraei SO, AlKubaisi BO, Ullah S, Anbar HS, El-Gamal R, Menon V, Abdel-Maksoud MS, Oh CH, El-Awady R, Gelsleichter NE, Pelletier J, Sévigny J, Iqbal J, Al-Tel TH, El-Gamal MI. Shahin AI, et al. Among authors: sevigny j. Eur J Med Chem. 2023 Jan 15;246:114958. doi: 10.1016/j.ejmech.2022.114958. Epub 2022 Nov 26. Eur J Med Chem. 2023. PMID: 36470105
Silencing NTPDase3 activity rehabilitates the osteogenic commitment of post-menopausal stem cell bone progenitors.
Noronha-Matos JB, Pinto-Cardoso R, Bessa-Andrês C, Magalhães-Cardoso MT, Ferreirinha F, Costa MA, Marinhas J, Freitas R, Lemos R, Vilaça A, Oliveira A, Pelletier J, Sévigny J, Correia-de-Sá P. Noronha-Matos JB, et al. Among authors: sevigny j. Stem Cell Res Ther. 2023 Apr 19;14(1):97. doi: 10.1186/s13287-023-03315-6. Stem Cell Res Ther. 2023. PMID: 37076930 Free PMC article.
Heparins are potent inhibitors of ectonucleotide pyrophosphatase/phospho-diesterase-1 (NPP1) - a promising target for the immunotherapy of cancer.
Lopez V, Schuh HJM, Mirza S, Vaaßen VJ, Schmidt MS, Sylvester K, Idris RM, Renn C, Schäkel L, Pelletier J, Sévigny J, Naggi A, Scheffler B, Lee SY, Bendas G, Müller CE. Lopez V, et al. Among authors: sevigny j. Front Immunol. 2023 Aug 29;14:1173634. doi: 10.3389/fimmu.2023.1173634. eCollection 2023. Front Immunol. 2023. PMID: 37711611 Free PMC article.
Synthesis, in vitro, and in silico studies of morpholine-based thiosemicarbazones as ectonucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors.
Tasleem M, Pelletier J, Sévigny J, Hussain Z, Khan A, Al-Harrasi A, El-Kott AF, Taslimi P, Negm S, Shafiq Z, Iqbal J. Tasleem M, et al. Among authors: sevigny j. Int J Biol Macromol. 2024 May;266(Pt 2):131068. doi: 10.1016/j.ijbiomac.2024.131068. Epub 2024 Mar 24. Int J Biol Macromol. 2024. PMID: 38531526
Ectonucleotidase inhibitors: an updated patent review (2017-2023).
Iqbal J, Bano S, Khan IA, Sévigny J, Huang Q. Iqbal J, et al. Among authors: sevigny j. Expert Opin Ther Pat. 2024 Nov;34(11):1167-1176. doi: 10.1080/13543776.2024.2423023. Epub 2024 Oct 30. Expert Opin Ther Pat. 2024. PMID: 39460640 Review.
366 results